Is Desmin Propensity to Aggregate Part of its Protective Function?

Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF). These desmin alterations are reversed by therapy, suggesting a causal role for the...

Descripción completa

Detalles Bibliográficos
Autores principales: Singh, Sonia R., Kadioglu, Hikmet, Patel, Krishna, Carrier, Lucie, Agnetti, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072738/
https://www.ncbi.nlm.nih.gov/pubmed/32093415
http://dx.doi.org/10.3390/cells9020491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072738/
https://www.ncbi.nlm.nih.gov/pubmed/32093415
http://dx.doi.org/10.3390/cells9020491

Ejemplares similares