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Is Desmin Propensity to Aggregate Part of its Protective Function?

Desmin is the major protein component of the intermediate filaments (IFs) cytoskeleton in muscle cells, including cardiac. The accumulation of cleaved and misfolded desmin is a cellular hallmark of heart failure (HF). These desmin alterations are reversed by therapy, suggesting a causal role for the...

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Detalles Bibliográficos
Autores principales:	Singh, Sonia R., Kadioglu, Hikmet, Patel, Krishna, Carrier, Lucie, Agnetti, Giulio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072738/ https://www.ncbi.nlm.nih.gov/pubmed/32093415 http://dx.doi.org/10.3390/cells9020491

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