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The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent proliferation of synovial tissues, which eventually leads to cartilage and bone destruction without effective treatments. Anti-citrullinated cyclic peptide/protein antibody (ACPA) and rheumatoid f...

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Autores principales: Ishikawa, Yuki, Terao, Chikashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072747/
https://www.ncbi.nlm.nih.gov/pubmed/32092988
http://dx.doi.org/10.3390/cells9020475
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author Ishikawa, Yuki
Terao, Chikashi
author_facet Ishikawa, Yuki
Terao, Chikashi
author_sort Ishikawa, Yuki
collection PubMed
description Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent proliferation of synovial tissues, which eventually leads to cartilage and bone destruction without effective treatments. Anti-citrullinated cyclic peptide/protein antibody (ACPA) and rheumatoid factor (RF) are two main characteristic autoantibodies found in RA patients and are associated with unfavorable disease outcomes. Although etiologies and causes of the disease have not been fully clarified yet, it is likely that interactive contributions of genetic and environmental factors play a main role in RA pathology. Previous works have demonstrated several genetic and environmental factors as risks of RA development and/or autoantibody productions. Among these, cigarette smoking and HLA-DRB1 are the well-established environmental and genetic risks, respectively. In this narrative review, we provide a recent update on genetic contributions to RA and the environmental risks of RA with a special focus on cigarette smoking and its impacts on RA pathology. We also describe gene–environmental interaction in RA pathogenesis with an emphasis on cigarette smoking and HLA-DRB1.
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spelling pubmed-70727472020-03-19 The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review Ishikawa, Yuki Terao, Chikashi Cells Review Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation and subsequent proliferation of synovial tissues, which eventually leads to cartilage and bone destruction without effective treatments. Anti-citrullinated cyclic peptide/protein antibody (ACPA) and rheumatoid factor (RF) are two main characteristic autoantibodies found in RA patients and are associated with unfavorable disease outcomes. Although etiologies and causes of the disease have not been fully clarified yet, it is likely that interactive contributions of genetic and environmental factors play a main role in RA pathology. Previous works have demonstrated several genetic and environmental factors as risks of RA development and/or autoantibody productions. Among these, cigarette smoking and HLA-DRB1 are the well-established environmental and genetic risks, respectively. In this narrative review, we provide a recent update on genetic contributions to RA and the environmental risks of RA with a special focus on cigarette smoking and its impacts on RA pathology. We also describe gene–environmental interaction in RA pathogenesis with an emphasis on cigarette smoking and HLA-DRB1. MDPI 2020-02-19 /pmc/articles/PMC7072747/ /pubmed/32092988 http://dx.doi.org/10.3390/cells9020475 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ishikawa, Yuki
Terao, Chikashi
The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review
title The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review
title_full The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review
title_fullStr The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review
title_full_unstemmed The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review
title_short The Impact of Cigarette Smoking on Risk of Rheumatoid Arthritis: A Narrative Review
title_sort impact of cigarette smoking on risk of rheumatoid arthritis: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072747/
https://www.ncbi.nlm.nih.gov/pubmed/32092988
http://dx.doi.org/10.3390/cells9020475
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