Evaluation of Toxic Amyloid β42 Oligomers in Rat Primary Cerebral Cortex Cells and Human iPS-derived Neurons Treated with 10-Me-Aplog-1, a New PKC Activator

Amyloid β42 (Aβ42), a causative agent of Alzheimer’s disease (AD), is derived extracellularly from Aβ precursor protein (APP) following the latter’s cleavage by β-secretase, but not α-secretase. Protein kinase Cα (PKCα) activation is known to increase α-secretase activity, thereby suppressing Aβ pro...

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Detalles Bibliográficos
Autores principales: Murakami, Kazuma, Yoshimura, Mayuko, Nakagawa, Shota, Kume, Toshiaki, Kondo, Takayuki, Inoue, Haruhisa, Irie, Kazuhiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072833/
https://www.ncbi.nlm.nih.gov/pubmed/32053979
http://dx.doi.org/10.3390/ijms21041179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072833/
https://www.ncbi.nlm.nih.gov/pubmed/32053979
http://dx.doi.org/10.3390/ijms21041179

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