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IL-33/IL-31 Axis in Osteoporosis

The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. He...

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Autores principales: De Martinis, Massimo, Sirufo, Maria Maddalena, Suppa, Mariano, Ginaldi, Lia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072890/
https://www.ncbi.nlm.nih.gov/pubmed/32069819
http://dx.doi.org/10.3390/ijms21041239
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author De Martinis, Massimo
Sirufo, Maria Maddalena
Suppa, Mariano
Ginaldi, Lia
author_facet De Martinis, Massimo
Sirufo, Maria Maddalena
Suppa, Mariano
Ginaldi, Lia
author_sort De Martinis, Massimo
collection PubMed
description The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. Here we focus on two newly discovered Th2 cytokines, IL-31 and IL-33, whose implications in osteoporosis are recently emerging. Clinical and experimental observations suggest an important role of the IL-33/IL-31 axis in osteoporosis. IL-33 induces IL-31 secretion by Th2 cells and inhibits RANKL-dependent osteoclastogenesis, thus counteracting bone loss. IL-31 influences Th1/Th17 osteoclastogenetic inflammation and limits Th2 osteoprotective processes, thus favoring osteoporosis. Better knowledge of the role of IL-31 and IL-33 and their receptor complexes in osteoporosis could provide an interesting perspective for the development of new and more effective therapies, possibly with less side effects.
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spelling pubmed-70728902020-03-19 IL-33/IL-31 Axis in Osteoporosis De Martinis, Massimo Sirufo, Maria Maddalena Suppa, Mariano Ginaldi, Lia Int J Mol Sci Review The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. Here we focus on two newly discovered Th2 cytokines, IL-31 and IL-33, whose implications in osteoporosis are recently emerging. Clinical and experimental observations suggest an important role of the IL-33/IL-31 axis in osteoporosis. IL-33 induces IL-31 secretion by Th2 cells and inhibits RANKL-dependent osteoclastogenesis, thus counteracting bone loss. IL-31 influences Th1/Th17 osteoclastogenetic inflammation and limits Th2 osteoprotective processes, thus favoring osteoporosis. Better knowledge of the role of IL-31 and IL-33 and their receptor complexes in osteoporosis could provide an interesting perspective for the development of new and more effective therapies, possibly with less side effects. MDPI 2020-02-13 /pmc/articles/PMC7072890/ /pubmed/32069819 http://dx.doi.org/10.3390/ijms21041239 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Martinis, Massimo
Sirufo, Maria Maddalena
Suppa, Mariano
Ginaldi, Lia
IL-33/IL-31 Axis in Osteoporosis
title IL-33/IL-31 Axis in Osteoporosis
title_full IL-33/IL-31 Axis in Osteoporosis
title_fullStr IL-33/IL-31 Axis in Osteoporosis
title_full_unstemmed IL-33/IL-31 Axis in Osteoporosis
title_short IL-33/IL-31 Axis in Osteoporosis
title_sort il-33/il-31 axis in osteoporosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072890/
https://www.ncbi.nlm.nih.gov/pubmed/32069819
http://dx.doi.org/10.3390/ijms21041239
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