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IL-33/IL-31 Axis in Osteoporosis
The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. He...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072890/ https://www.ncbi.nlm.nih.gov/pubmed/32069819 http://dx.doi.org/10.3390/ijms21041239 |
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author | De Martinis, Massimo Sirufo, Maria Maddalena Suppa, Mariano Ginaldi, Lia |
author_facet | De Martinis, Massimo Sirufo, Maria Maddalena Suppa, Mariano Ginaldi, Lia |
author_sort | De Martinis, Massimo |
collection | PubMed |
description | The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. Here we focus on two newly discovered Th2 cytokines, IL-31 and IL-33, whose implications in osteoporosis are recently emerging. Clinical and experimental observations suggest an important role of the IL-33/IL-31 axis in osteoporosis. IL-33 induces IL-31 secretion by Th2 cells and inhibits RANKL-dependent osteoclastogenesis, thus counteracting bone loss. IL-31 influences Th1/Th17 osteoclastogenetic inflammation and limits Th2 osteoprotective processes, thus favoring osteoporosis. Better knowledge of the role of IL-31 and IL-33 and their receptor complexes in osteoporosis could provide an interesting perspective for the development of new and more effective therapies, possibly with less side effects. |
format | Online Article Text |
id | pubmed-7072890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70728902020-03-19 IL-33/IL-31 Axis in Osteoporosis De Martinis, Massimo Sirufo, Maria Maddalena Suppa, Mariano Ginaldi, Lia Int J Mol Sci Review The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known. Here we focus on two newly discovered Th2 cytokines, IL-31 and IL-33, whose implications in osteoporosis are recently emerging. Clinical and experimental observations suggest an important role of the IL-33/IL-31 axis in osteoporosis. IL-33 induces IL-31 secretion by Th2 cells and inhibits RANKL-dependent osteoclastogenesis, thus counteracting bone loss. IL-31 influences Th1/Th17 osteoclastogenetic inflammation and limits Th2 osteoprotective processes, thus favoring osteoporosis. Better knowledge of the role of IL-31 and IL-33 and their receptor complexes in osteoporosis could provide an interesting perspective for the development of new and more effective therapies, possibly with less side effects. MDPI 2020-02-13 /pmc/articles/PMC7072890/ /pubmed/32069819 http://dx.doi.org/10.3390/ijms21041239 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review De Martinis, Massimo Sirufo, Maria Maddalena Suppa, Mariano Ginaldi, Lia IL-33/IL-31 Axis in Osteoporosis |
title | IL-33/IL-31 Axis in Osteoporosis |
title_full | IL-33/IL-31 Axis in Osteoporosis |
title_fullStr | IL-33/IL-31 Axis in Osteoporosis |
title_full_unstemmed | IL-33/IL-31 Axis in Osteoporosis |
title_short | IL-33/IL-31 Axis in Osteoporosis |
title_sort | il-33/il-31 axis in osteoporosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072890/ https://www.ncbi.nlm.nih.gov/pubmed/32069819 http://dx.doi.org/10.3390/ijms21041239 |
work_keys_str_mv | AT demartinismassimo il33il31axisinosteoporosis AT sirufomariamaddalena il33il31axisinosteoporosis AT suppamariano il33il31axisinosteoporosis AT ginaldilia il33il31axisinosteoporosis |