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Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies
Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline of cancer patients, since it is a negative predictor of treatment outcome and associated to increased mortality. However, despite its toxicity...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072891/ https://www.ncbi.nlm.nih.gov/pubmed/32069876 http://dx.doi.org/10.3390/ijms21041242 |
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author | Conte, Elena Bresciani, Elena Rizzi, Laura Cappellari, Ornella De Luca, Annamaria Torsello, Antonio Liantonio, Antonella |
author_facet | Conte, Elena Bresciani, Elena Rizzi, Laura Cappellari, Ornella De Luca, Annamaria Torsello, Antonio Liantonio, Antonella |
author_sort | Conte, Elena |
collection | PubMed |
description | Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline of cancer patients, since it is a negative predictor of treatment outcome and associated to increased mortality. However, despite its toxicity even at low doses, cisplatin remains the first-line therapy for several types of solid tumors. Thus, effective pharmacological treatments counteracting or minimizing cisplatin-induced muscle wasting are urgently needed. The dissection of the molecular pathways responsible for cisplatin-induced muscle dysfunction gives the possibility to identify novel promising therapeutic targets. In this context, the use of animal model of cisplatin-induced cachexia is very useful. Here, we report an update of the most relevant researches on the mechanisms underlying cisplatin-induced muscle wasting and on the most promising potential therapeutic options to preserve muscle mass and function. |
format | Online Article Text |
id | pubmed-7072891 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70728912020-03-19 Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies Conte, Elena Bresciani, Elena Rizzi, Laura Cappellari, Ornella De Luca, Annamaria Torsello, Antonio Liantonio, Antonella Int J Mol Sci Review Among the severe side effects induced by cisplatin chemotherapy, muscle wasting is the most relevant one. This effect is a major cause for a clinical decline of cancer patients, since it is a negative predictor of treatment outcome and associated to increased mortality. However, despite its toxicity even at low doses, cisplatin remains the first-line therapy for several types of solid tumors. Thus, effective pharmacological treatments counteracting or minimizing cisplatin-induced muscle wasting are urgently needed. The dissection of the molecular pathways responsible for cisplatin-induced muscle dysfunction gives the possibility to identify novel promising therapeutic targets. In this context, the use of animal model of cisplatin-induced cachexia is very useful. Here, we report an update of the most relevant researches on the mechanisms underlying cisplatin-induced muscle wasting and on the most promising potential therapeutic options to preserve muscle mass and function. MDPI 2020-02-13 /pmc/articles/PMC7072891/ /pubmed/32069876 http://dx.doi.org/10.3390/ijms21041242 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Conte, Elena Bresciani, Elena Rizzi, Laura Cappellari, Ornella De Luca, Annamaria Torsello, Antonio Liantonio, Antonella Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies |
title | Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies |
title_full | Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies |
title_fullStr | Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies |
title_full_unstemmed | Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies |
title_short | Cisplatin-Induced Skeletal Muscle Dysfunction: Mechanisms and Counteracting Therapeutic Strategies |
title_sort | cisplatin-induced skeletal muscle dysfunction: mechanisms and counteracting therapeutic strategies |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072891/ https://www.ncbi.nlm.nih.gov/pubmed/32069876 http://dx.doi.org/10.3390/ijms21041242 |
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