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Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer
Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review, we aim to explore the links between MAPK signalling and...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072904/ https://www.ncbi.nlm.nih.gov/pubmed/32069845 http://dx.doi.org/10.3390/ijms21041241 |
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author | Donohoe, Fionán Wilkinson, Michael Baxter, Eva Brennan, Donal J. |
author_facet | Donohoe, Fionán Wilkinson, Michael Baxter, Eva Brennan, Donal J. |
author_sort | Donohoe, Fionán |
collection | PubMed |
description | Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review, we aim to explore the links between MAPK signalling and obesity-related cancer. We focus mostly on p38 and JNK MAPK, as the role of ERK remains unclear. These links are seen through the implication of MAPK in obesity-related immune paralysis as well as through effects on the endoplasmic reticulum stress response and activation of aromatase. By way of example, we highlight areas of interest and possibilities for future research in endometrioid endometrial cancer and hepatocellular carcinoma associated with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and MAPK. |
format | Online Article Text |
id | pubmed-7072904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70729042020-03-19 Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer Donohoe, Fionán Wilkinson, Michael Baxter, Eva Brennan, Donal J. Int J Mol Sci Review Obesity is a major public health concern worldwide. The increased risk of certain types of cancer is now an established deleterious consequence of obesity, although the molecular mechanisms of this are not completely understood. In this review, we aim to explore the links between MAPK signalling and obesity-related cancer. We focus mostly on p38 and JNK MAPK, as the role of ERK remains unclear. These links are seen through the implication of MAPK in obesity-related immune paralysis as well as through effects on the endoplasmic reticulum stress response and activation of aromatase. By way of example, we highlight areas of interest and possibilities for future research in endometrioid endometrial cancer and hepatocellular carcinoma associated with non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and MAPK. MDPI 2020-02-13 /pmc/articles/PMC7072904/ /pubmed/32069845 http://dx.doi.org/10.3390/ijms21041241 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Donohoe, Fionán Wilkinson, Michael Baxter, Eva Brennan, Donal J. Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer |
title | Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer |
title_full | Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer |
title_fullStr | Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer |
title_full_unstemmed | Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer |
title_short | Mitogen-Activated Protein Kinase (MAPK) and Obesity-Related Cancer |
title_sort | mitogen-activated protein kinase (mapk) and obesity-related cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072904/ https://www.ncbi.nlm.nih.gov/pubmed/32069845 http://dx.doi.org/10.3390/ijms21041241 |
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