RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity

Scrapie infection, which converts cellular prion protein (PrP(C)) into the pathological and infectious isoform (PrP(Sc)), leads to neuronal cell death, glial cell activation and PrP(Sc) accumulation. Previous studies reported that PrP(C) regulates RhoA/Rho-associated kinase (ROCK) signaling and that...

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Detalles Bibliográficos
Autores principales: Kim, Hee-Jun, Kim, Mo-Jong, Mostafa, Mohd Najib, Park, Jeong-Ho, Choi, Hong-Seok, Kim, Yong-Sun, Choi, Eun-Kyoung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072953/
https://www.ncbi.nlm.nih.gov/pubmed/32070020
http://dx.doi.org/10.3390/ijms21041255

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072953/
https://www.ncbi.nlm.nih.gov/pubmed/32070020
http://dx.doi.org/10.3390/ijms21041255

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