Cargando…
RhoA/ROCK Regulates Prion Pathogenesis by Controlling Connexin 43 Activity
Scrapie infection, which converts cellular prion protein (PrP(C)) into the pathological and infectious isoform (PrP(Sc)), leads to neuronal cell death, glial cell activation and PrP(Sc) accumulation. Previous studies reported that PrP(C) regulates RhoA/Rho-associated kinase (ROCK) signaling and that...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072953/ https://www.ncbi.nlm.nih.gov/pubmed/32070020 http://dx.doi.org/10.3390/ijms21041255 |