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Differential Signaling Profiles of MC4R Mutations with Three Different Ligands

The melanocortin 4 receptor (MC4R) is a key player in hypothalamic weight regulation and energy expenditure as part of the leptin–melanocortin pathway. Mutations in this G protein coupled receptor (GPCR) are the most common cause for monogenetic obesity, which appears to be mediated by changes in th...

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Detalles Bibliográficos
Autores principales:	Paisdzior, Sarah, Dimitriou, Ioanna Maria, Schöpe, Paul Curtis, Annibale, Paolo, Scheerer, Patrick, Krude, Heiko, Lohse, Martin J., Biebermann, Heike, Kühnen, Peter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072973/ https://www.ncbi.nlm.nih.gov/pubmed/32059383 http://dx.doi.org/10.3390/ijms21041224

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