High-Resolution Confocal Fluorescence Imaging of Serine Hydrolase Activity in Cryosections – Application to Glioma Brain Unveils Activity Hotspots Originating from Tumor-Associated Neutrophils

BACKGROUND: Serine hydrolases (SHs) are a functionally diverse family of enzymes playing pivotal roles in health and disease and have emerged as important therapeutic targets in many clinical conditions. Activity-based protein profiling (ABPP) using fluorophosphonate (FP) probes has been a powerful...

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Detalles Bibliográficos
Autores principales: Aaltonen, Niina, Singha, Prosanta K., Jakupović, Hermina, Wirth, Thomas, Samaranayake, Haritha, Pasonen-Seppänen, Sanna, Rilla, Kirsi, Varjosalo, Markku, Edgington-Mitchell, Laura E., Kasperkiewicz, Paulina, Drag, Marcin, Kälvälä, Sara, Moisio, Eemeli, Savinainen, Juha R., Laitinen, Jarmo T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073015/
https://www.ncbi.nlm.nih.gov/pubmed/32190011
http://dx.doi.org/10.1186/s12575-020-00118-4

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