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Autoantibody Biomarkers in Rheumatic Diseases
Autoantibodies encountered in patients with systemic rheumatic diseases bear clinical significance as a biomarker to help or predict diagnosis, clinical phenotypes, prognosis, and treatment decision-making. Furthermore, evidence has accumulated regarding the active involvement of disease-specific or...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073052/ https://www.ncbi.nlm.nih.gov/pubmed/32085664 http://dx.doi.org/10.3390/ijms21041382 |
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author | Kang, Eun Ha Ha, You-Jung Lee, Yun Jong |
author_facet | Kang, Eun Ha Ha, You-Jung Lee, Yun Jong |
author_sort | Kang, Eun Ha |
collection | PubMed |
description | Autoantibodies encountered in patients with systemic rheumatic diseases bear clinical significance as a biomarker to help or predict diagnosis, clinical phenotypes, prognosis, and treatment decision-making. Furthermore, evidence has accumulated regarding the active involvement of disease-specific or disease-associated autoantibodies in the pathogenic process beyond simple association with the disease, and such knowledge has become essential for us to better understand the clinical value of autoantibodies as a biomarker. This review will focus on the current update on the autoantibodies of four rheumatic diseases (rheumatoid arthritis, myositis, systemic sclerosis, and anti-neutrophil cytoplasmic antibody associated vasculitis) where there has been a tremendous progress in our understanding on their biological effects and clinical use. |
format | Online Article Text |
id | pubmed-7073052 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70730522020-03-19 Autoantibody Biomarkers in Rheumatic Diseases Kang, Eun Ha Ha, You-Jung Lee, Yun Jong Int J Mol Sci Review Autoantibodies encountered in patients with systemic rheumatic diseases bear clinical significance as a biomarker to help or predict diagnosis, clinical phenotypes, prognosis, and treatment decision-making. Furthermore, evidence has accumulated regarding the active involvement of disease-specific or disease-associated autoantibodies in the pathogenic process beyond simple association with the disease, and such knowledge has become essential for us to better understand the clinical value of autoantibodies as a biomarker. This review will focus on the current update on the autoantibodies of four rheumatic diseases (rheumatoid arthritis, myositis, systemic sclerosis, and anti-neutrophil cytoplasmic antibody associated vasculitis) where there has been a tremendous progress in our understanding on their biological effects and clinical use. MDPI 2020-02-18 /pmc/articles/PMC7073052/ /pubmed/32085664 http://dx.doi.org/10.3390/ijms21041382 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kang, Eun Ha Ha, You-Jung Lee, Yun Jong Autoantibody Biomarkers in Rheumatic Diseases |
title | Autoantibody Biomarkers in Rheumatic Diseases |
title_full | Autoantibody Biomarkers in Rheumatic Diseases |
title_fullStr | Autoantibody Biomarkers in Rheumatic Diseases |
title_full_unstemmed | Autoantibody Biomarkers in Rheumatic Diseases |
title_short | Autoantibody Biomarkers in Rheumatic Diseases |
title_sort | autoantibody biomarkers in rheumatic diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073052/ https://www.ncbi.nlm.nih.gov/pubmed/32085664 http://dx.doi.org/10.3390/ijms21041382 |
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