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Targeting Neurovascular Interaction in Retinal Disorders
The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and experimental evidence suggests that neuronal metab...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073081/ https://www.ncbi.nlm.nih.gov/pubmed/32098361 http://dx.doi.org/10.3390/ijms21041503 |
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author | Fu, Zhongjie Sun, Ye Cakir, Bertan Tomita, Yohei Huang, Shuo Wang, Zhongxiao Liu, Chi-Hsiu S. Cho, Steve Britton, William S. Kern, Timothy Antonetti, David A. Hellström, Ann E.H. Smith, Lois |
author_facet | Fu, Zhongjie Sun, Ye Cakir, Bertan Tomita, Yohei Huang, Shuo Wang, Zhongxiao Liu, Chi-Hsiu S. Cho, Steve Britton, William S. Kern, Timothy Antonetti, David A. Hellström, Ann E.H. Smith, Lois |
author_sort | Fu, Zhongjie |
collection | PubMed |
description | The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and experimental evidence suggests that neuronal metabolic needs control both normal retinal vascular development and pathological aberrant vascular growth. Particularly, photoreceptors, with the highest density of mitochondria in the body, regulate retinal vascular development by modulating angiogenic and inflammatory factors. Photoreceptor metabolic dysfunction, oxidative stress, and inflammation may cause adaptive but ultimately pathological retinal vascular responses, leading to blindness. Here we focus on the factors involved in neurovascular interactions, which are potential therapeutic targets to decrease energy demand and/or to increase energy production for neovascular retinal disorders. |
format | Online Article Text |
id | pubmed-7073081 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70730812020-03-19 Targeting Neurovascular Interaction in Retinal Disorders Fu, Zhongjie Sun, Ye Cakir, Bertan Tomita, Yohei Huang, Shuo Wang, Zhongxiao Liu, Chi-Hsiu S. Cho, Steve Britton, William S. Kern, Timothy Antonetti, David A. Hellström, Ann E.H. Smith, Lois Int J Mol Sci Review The tightly structured neural retina has a unique vascular network comprised of three interconnected plexuses in the inner retina (and choroid for outer retina), which provide oxygen and nutrients to neurons to maintain normal function. Clinical and experimental evidence suggests that neuronal metabolic needs control both normal retinal vascular development and pathological aberrant vascular growth. Particularly, photoreceptors, with the highest density of mitochondria in the body, regulate retinal vascular development by modulating angiogenic and inflammatory factors. Photoreceptor metabolic dysfunction, oxidative stress, and inflammation may cause adaptive but ultimately pathological retinal vascular responses, leading to blindness. Here we focus on the factors involved in neurovascular interactions, which are potential therapeutic targets to decrease energy demand and/or to increase energy production for neovascular retinal disorders. MDPI 2020-02-22 /pmc/articles/PMC7073081/ /pubmed/32098361 http://dx.doi.org/10.3390/ijms21041503 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fu, Zhongjie Sun, Ye Cakir, Bertan Tomita, Yohei Huang, Shuo Wang, Zhongxiao Liu, Chi-Hsiu S. Cho, Steve Britton, William S. Kern, Timothy Antonetti, David A. Hellström, Ann E.H. Smith, Lois Targeting Neurovascular Interaction in Retinal Disorders |
title | Targeting Neurovascular Interaction in Retinal Disorders |
title_full | Targeting Neurovascular Interaction in Retinal Disorders |
title_fullStr | Targeting Neurovascular Interaction in Retinal Disorders |
title_full_unstemmed | Targeting Neurovascular Interaction in Retinal Disorders |
title_short | Targeting Neurovascular Interaction in Retinal Disorders |
title_sort | targeting neurovascular interaction in retinal disorders |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073081/ https://www.ncbi.nlm.nih.gov/pubmed/32098361 http://dx.doi.org/10.3390/ijms21041503 |
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