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The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle

RNA virus genomes are multifunctional entities endowed with conserved structural elements that control translation, replication and encapsidation, among other processes. The preservation of these structural RNA elements constraints the genomic sequence variability. The hepatitis C virus (HCV) genome...

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Autores principales: Romero-López, Cristina, Berzal-Herranz, Alfredo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073135/
https://www.ncbi.nlm.nih.gov/pubmed/32098260
http://dx.doi.org/10.3390/ijms21041479
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author Romero-López, Cristina
Berzal-Herranz, Alfredo
author_facet Romero-López, Cristina
Berzal-Herranz, Alfredo
author_sort Romero-López, Cristina
collection PubMed
description RNA virus genomes are multifunctional entities endowed with conserved structural elements that control translation, replication and encapsidation, among other processes. The preservation of these structural RNA elements constraints the genomic sequence variability. The hepatitis C virus (HCV) genome is a positive, single-stranded RNA molecule with numerous conserved structural elements that manage different steps during the infection cycle. Their function is ensured by the association of protein factors, but also by the establishment of complex, active, long-range RNA-RNA interaction networks-the so-called HCV RNA interactome. This review describes the RNA genome functions mediated via RNA-RNA contacts, and revisits some canonical ideas regarding the role of functional high-order structures during the HCV infective cycle. By outlining the roles of long-range RNA-RNA interactions from translation to virion budding, and the functional domains involved, this work provides an overview of the HCV genome as a dynamic device that manages the course of viral infection.
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spelling pubmed-70731352020-03-19 The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle Romero-López, Cristina Berzal-Herranz, Alfredo Int J Mol Sci Review RNA virus genomes are multifunctional entities endowed with conserved structural elements that control translation, replication and encapsidation, among other processes. The preservation of these structural RNA elements constraints the genomic sequence variability. The hepatitis C virus (HCV) genome is a positive, single-stranded RNA molecule with numerous conserved structural elements that manage different steps during the infection cycle. Their function is ensured by the association of protein factors, but also by the establishment of complex, active, long-range RNA-RNA interaction networks-the so-called HCV RNA interactome. This review describes the RNA genome functions mediated via RNA-RNA contacts, and revisits some canonical ideas regarding the role of functional high-order structures during the HCV infective cycle. By outlining the roles of long-range RNA-RNA interactions from translation to virion budding, and the functional domains involved, this work provides an overview of the HCV genome as a dynamic device that manages the course of viral infection. MDPI 2020-02-21 /pmc/articles/PMC7073135/ /pubmed/32098260 http://dx.doi.org/10.3390/ijms21041479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Romero-López, Cristina
Berzal-Herranz, Alfredo
The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
title The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
title_full The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
title_fullStr The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
title_full_unstemmed The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
title_short The Role of the RNA-RNA Interactome in the Hepatitis C Virus Life Cycle
title_sort role of the rna-rna interactome in the hepatitis c virus life cycle
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073135/
https://www.ncbi.nlm.nih.gov/pubmed/32098260
http://dx.doi.org/10.3390/ijms21041479
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