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A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer
The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073181/ https://www.ncbi.nlm.nih.gov/pubmed/32033142 http://dx.doi.org/10.3390/cancers12020352 |
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author | Liu, Li Yan, Lu Liao, Ning Wu, Wan-Qin Shi, Jun-Ling |
author_facet | Liu, Li Yan, Lu Liao, Ning Wu, Wan-Qin Shi, Jun-Ling |
author_sort | Liu, Li |
collection | PubMed |
description | The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target. |
format | Online Article Text |
id | pubmed-7073181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70731812020-03-19 A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer Liu, Li Yan, Lu Liao, Ning Wu, Wan-Qin Shi, Jun-Ling Cancers (Basel) Review The difficulty of early diagnosis and the development of drug resistance are two major barriers to the successful treatment of cancer. Autophagy plays a crucial role in several cellular functions, and its dysregulation is associated with both tumorigenesis and drug resistance. Unc-51-like kinase 1 (ULK1) is a serine/threonine kinase that participates in the initiation of autophagy. Many studies have indicated that compounds that directly or indirectly target ULK1 could be used for tumor therapy. However, reports of the therapeutic effects of these compounds have come to conflicting conclusions. In this work, we reviewed recent studies related to the effects of ULK1 on the regulation of autophagy and the development of drug resistance in cancers, with the aim of clarifying the mechanistic underpinnings of this therapeutic target. MDPI 2020-02-04 /pmc/articles/PMC7073181/ /pubmed/32033142 http://dx.doi.org/10.3390/cancers12020352 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Liu, Li Yan, Lu Liao, Ning Wu, Wan-Qin Shi, Jun-Ling A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
title | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
title_full | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
title_fullStr | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
title_full_unstemmed | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
title_short | A Review of ULK1-Mediated Autophagy in Drug Resistance of Cancer |
title_sort | review of ulk1-mediated autophagy in drug resistance of cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073181/ https://www.ncbi.nlm.nih.gov/pubmed/32033142 http://dx.doi.org/10.3390/cancers12020352 |
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