Deletion of Von Hippel–Lindau Interferes with Hyper Osmolality Induced Gene Expression and Induces an Unfavorable Gene Expression Pattern

Loss of von Hippel–Lindau (VHL) protein function can be found in more than 90% of patients with clear cell renal carcinoma (ccRCC). Mice lacking Vhl function in the kidneys have urine concentration defects due to postulated reduction of the hyperosmotic gradient. Hyperosmolality is a kidney-specific...

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Detalles Bibliográficos
Autores principales: Groß, Alexander, Chernyakov, Dmitry, Gallwitz, Lisa, Bornkessel, Nicola, Edemir, Bayram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073186/
https://www.ncbi.nlm.nih.gov/pubmed/32059438
http://dx.doi.org/10.3390/cancers12020420

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