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Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer

Pancreatic cancer is an aggressive malignancy and the seventh leading cause of global cancer deaths in industrialised countries. More than 80% of patients suffer from significant weight loss at diagnosis and over time tend to develop severe cachexia. A major cause of weight loss is malnutrition. Pat...

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Autores principales: Pezzilli, Raffaele, Caccialanza, Riccardo, Capurso, Gabriele, Brunetti, Oronzo, Milella, Michele, Falconi, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073203/
https://www.ncbi.nlm.nih.gov/pubmed/31979186
http://dx.doi.org/10.3390/cancers12020275
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author Pezzilli, Raffaele
Caccialanza, Riccardo
Capurso, Gabriele
Brunetti, Oronzo
Milella, Michele
Falconi, Massimo
author_facet Pezzilli, Raffaele
Caccialanza, Riccardo
Capurso, Gabriele
Brunetti, Oronzo
Milella, Michele
Falconi, Massimo
author_sort Pezzilli, Raffaele
collection PubMed
description Pancreatic cancer is an aggressive malignancy and the seventh leading cause of global cancer deaths in industrialised countries. More than 80% of patients suffer from significant weight loss at diagnosis and over time tend to develop severe cachexia. A major cause of weight loss is malnutrition. Patients may experience pancreatic exocrine insufficiency (PEI) before diagnosis, during nonsurgical treatment, and/or following surgery. PEI is difficult to diagnose because testing is cumbersome. Consequently, PEI is often detected clinically, especially in non-specialised centres, and treated empirically. In this position paper, we review the current literature on nutritional support and pancreatic enzyme replacement therapy (PERT) in patients with operable and non-operable pancreatic cancer. To increase awareness on the importance of PERT in pancreatic patients, we provide recommendations based on literature evidence, and when data were lacking, based on our own clinical experience.
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spelling pubmed-70732032020-03-19 Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer Pezzilli, Raffaele Caccialanza, Riccardo Capurso, Gabriele Brunetti, Oronzo Milella, Michele Falconi, Massimo Cancers (Basel) Review Pancreatic cancer is an aggressive malignancy and the seventh leading cause of global cancer deaths in industrialised countries. More than 80% of patients suffer from significant weight loss at diagnosis and over time tend to develop severe cachexia. A major cause of weight loss is malnutrition. Patients may experience pancreatic exocrine insufficiency (PEI) before diagnosis, during nonsurgical treatment, and/or following surgery. PEI is difficult to diagnose because testing is cumbersome. Consequently, PEI is often detected clinically, especially in non-specialised centres, and treated empirically. In this position paper, we review the current literature on nutritional support and pancreatic enzyme replacement therapy (PERT) in patients with operable and non-operable pancreatic cancer. To increase awareness on the importance of PERT in pancreatic patients, we provide recommendations based on literature evidence, and when data were lacking, based on our own clinical experience. MDPI 2020-01-22 /pmc/articles/PMC7073203/ /pubmed/31979186 http://dx.doi.org/10.3390/cancers12020275 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Pezzilli, Raffaele
Caccialanza, Riccardo
Capurso, Gabriele
Brunetti, Oronzo
Milella, Michele
Falconi, Massimo
Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer
title Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer
title_full Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer
title_fullStr Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer
title_full_unstemmed Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer
title_short Pancreatic Enzyme Replacement Therapy in Pancreatic Cancer
title_sort pancreatic enzyme replacement therapy in pancreatic cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073203/
https://www.ncbi.nlm.nih.gov/pubmed/31979186
http://dx.doi.org/10.3390/cancers12020275
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