Novel Quinoline Compounds Active in Cancer Cells through Coupled DNA Methyltransferase Inhibition and Degradation

DNA methyltransferases (DNMTs) play a relevant role in epigenetic control of cancer cell survival and proliferation. Since only two DNMT inhibitors (azacitidine and decitabine) have been approved to date for the treatment of hematological malignancies, the development of novel potent and specific in...

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Detalles Bibliográficos
Autores principales: Zwergel, Clemens, Fioravanti, Rossella, Stazi, Giulia, Sarno, Federica, Battistelli, Cecilia, Romanelli, Annalisa, Nebbioso, Angela, Mendes, Eduarda, Paulo, Alexandra, Strippoli, Raffaele, Tripodi, Marco, Pechalrieu, Dany, Arimondo, Paola B., De Luca, Teresa, Del Bufalo, Donatella, Trisciuoglio, Daniela, Altucci, Lucia, Valente, Sergio, Mai, Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073229/
https://www.ncbi.nlm.nih.gov/pubmed/32075099
http://dx.doi.org/10.3390/cancers12020447

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073229/
https://www.ncbi.nlm.nih.gov/pubmed/32075099
http://dx.doi.org/10.3390/cancers12020447

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