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Mechanism- and Immune Landscape-Based Ranking of Therapeutic Responsiveness of 22 Major Human Cancers to Next Generation Anti-CTLA-4 Antibodies

Background: CTLA-4 was the first immune checkpoint targeted for cancer therapy and the first target validated by the FDA (Food and Drug Administration) after approval of the anti-CTLA-4 antibody, Ipilimumab. However, clinical response rates to anti-CTLA-4 antibodies are lower while the rates of immu...

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Detalles Bibliográficos
Autores principales:	Zhang, Peng, Xiong, Xinxin, Rolfo, Christian, Du, Xuexiang, Zhang, Yan, Yang, Han, Russo, Alessandro, Devenport, Martin, Zhou, Penghui, Liu, Yang, Zheng, Pan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073233/ https://www.ncbi.nlm.nih.gov/pubmed/31991588 http://dx.doi.org/10.3390/cancers12020284

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