Cargando…

3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study

PURPOSE: To design a novel high-dose-rate intracavitary applicator which may lead to enhanced dose modulation in the brachytherapy of gynecological cancers. MATERIAL AND METHODS: A novel brachytherapy applicator, auxiliary equipment and quality control phantom were modeled in SketchUp Pro 2017 model...

Descripción completa

Detalles Bibliográficos
Autores principales: Biltekin, Fatih, Akyol, Husnu Fadil, Gültekin, Melis, Yildiz, Ferah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073342/
https://www.ncbi.nlm.nih.gov/pubmed/32190066
http://dx.doi.org/10.5114/jcb.2020.92407
_version_ 1783506602586800128
author Biltekin, Fatih
Akyol, Husnu Fadil
Gültekin, Melis
Yildiz, Ferah
author_facet Biltekin, Fatih
Akyol, Husnu Fadil
Gültekin, Melis
Yildiz, Ferah
author_sort Biltekin, Fatih
collection PubMed
description PURPOSE: To design a novel high-dose-rate intracavitary applicator which may lead to enhanced dose modulation in the brachytherapy of gynecological cancers. MATERIAL AND METHODS: A novel brachytherapy applicator, auxiliary equipment and quality control phantom were modeled in SketchUp Pro 2017 modeling software and printed out from a MakerBot Replicator Z18 three-dimensional printer. As a printing material polylactic acid (PLA) filament was used and compensator materials including aluminum, stainless-steel and Cerrobend alloy were selected according to their radiation attenuation properties. To evaluate the feasibility of the novel applicator, two sets of measurements were performed in a Varian GammaMed iX Plus high-dose rate iridium-192 ((192)Ir) brachytherapy unit and all of the treatment plans were calculated in Varian BrachyVision treatment planning system v.8.9 with TG43-based formalism. In the first step, catheter and source-dwell positioning accuracy, reproducibility of catheter and source positions, linearity of relative dose with changing dwell times and compensator materials were tested to evaluate the mechanical stability of the designed applicator. In the second step, to validate the dosimetric accuracy of the novel applicator measured point dose and two-dimensional dose distributions in homogeneous medium were compared with calculated data in the treatment planning system using PTW VeriSoft v.5.1 software. RESULTS: In mechanical quality control tests source-dwell positioning accuracy and linearity of the designed applicator were measured as ≤ 0.5 mm and ≤ 1.5%, respectively. Reproducibility of the treatment planning was ≥ 97.7% for gamma evaluation criteria of 1 mm distance to agreement and 1% dose difference of local dose. In dosimetric quality control tests, maximum difference between measured and calculated point dose was found as 3.8% in homogeneous medium. In two-dimensional analysis, the number of passing points was greater than 90% for all measurements using gamma evaluation criteria of 3 mm distance to agreement and 3% dose difference of local dose. CONCLUSIONS: The novel brachytherapy applicator met the necessary requirements in quality control tests.
format Online
Article
Text
id pubmed-7073342
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Termedia Publishing House
record_format MEDLINE/PubMed
spelling pubmed-70733422020-03-18 3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study Biltekin, Fatih Akyol, Husnu Fadil Gültekin, Melis Yildiz, Ferah J Contemp Brachytherapy Original Paper PURPOSE: To design a novel high-dose-rate intracavitary applicator which may lead to enhanced dose modulation in the brachytherapy of gynecological cancers. MATERIAL AND METHODS: A novel brachytherapy applicator, auxiliary equipment and quality control phantom were modeled in SketchUp Pro 2017 modeling software and printed out from a MakerBot Replicator Z18 three-dimensional printer. As a printing material polylactic acid (PLA) filament was used and compensator materials including aluminum, stainless-steel and Cerrobend alloy were selected according to their radiation attenuation properties. To evaluate the feasibility of the novel applicator, two sets of measurements were performed in a Varian GammaMed iX Plus high-dose rate iridium-192 ((192)Ir) brachytherapy unit and all of the treatment plans were calculated in Varian BrachyVision treatment planning system v.8.9 with TG43-based formalism. In the first step, catheter and source-dwell positioning accuracy, reproducibility of catheter and source positions, linearity of relative dose with changing dwell times and compensator materials were tested to evaluate the mechanical stability of the designed applicator. In the second step, to validate the dosimetric accuracy of the novel applicator measured point dose and two-dimensional dose distributions in homogeneous medium were compared with calculated data in the treatment planning system using PTW VeriSoft v.5.1 software. RESULTS: In mechanical quality control tests source-dwell positioning accuracy and linearity of the designed applicator were measured as ≤ 0.5 mm and ≤ 1.5%, respectively. Reproducibility of the treatment planning was ≥ 97.7% for gamma evaluation criteria of 1 mm distance to agreement and 1% dose difference of local dose. In dosimetric quality control tests, maximum difference between measured and calculated point dose was found as 3.8% in homogeneous medium. In two-dimensional analysis, the number of passing points was greater than 90% for all measurements using gamma evaluation criteria of 3 mm distance to agreement and 3% dose difference of local dose. CONCLUSIONS: The novel brachytherapy applicator met the necessary requirements in quality control tests. Termedia Publishing House 2020-02-28 2020-02 /pmc/articles/PMC7073342/ /pubmed/32190066 http://dx.doi.org/10.5114/jcb.2020.92407 Text en Copyright © 2020 Termedia http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0). License (http://creativecommons.org/licenses/by-nc-sa/4.0/)
spellingShingle Original Paper
Biltekin, Fatih
Akyol, Husnu Fadil
Gültekin, Melis
Yildiz, Ferah
3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
title 3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
title_full 3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
title_fullStr 3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
title_full_unstemmed 3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
title_short 3D printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
title_sort 3d printer-based novel intensity-modulated vaginal brachytherapy applicator: feasibility study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073342/
https://www.ncbi.nlm.nih.gov/pubmed/32190066
http://dx.doi.org/10.5114/jcb.2020.92407
work_keys_str_mv AT biltekinfatih 3dprinterbasednovelintensitymodulatedvaginalbrachytherapyapplicatorfeasibilitystudy
AT akyolhusnufadil 3dprinterbasednovelintensitymodulatedvaginalbrachytherapyapplicatorfeasibilitystudy
AT gultekinmelis 3dprinterbasednovelintensitymodulatedvaginalbrachytherapyapplicatorfeasibilitystudy
AT yildizferah 3dprinterbasednovelintensitymodulatedvaginalbrachytherapyapplicatorfeasibilitystudy