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Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically

INTRODUCTION: The research of auxiliary diagnosis has always been one of the hotspots in the world. The implementation of auxiliary diagnosis support algorithm for medical text data faces challenges with interpretability and creditability. The improvement of clinical diagnostic techniques means not...

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Autores principales: Liu, Yuliang, Zhang, Quan, Zhao, Geng, Liu, Guohua, Liu, Zhiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073442/
https://www.ncbi.nlm.nih.gov/pubmed/32210601
http://dx.doi.org/10.2147/DMSO.S242585
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author Liu, Yuliang
Zhang, Quan
Zhao, Geng
Liu, Guohua
Liu, Zhiang
author_facet Liu, Yuliang
Zhang, Quan
Zhao, Geng
Liu, Guohua
Liu, Zhiang
author_sort Liu, Yuliang
collection PubMed
description INTRODUCTION: The research of auxiliary diagnosis has always been one of the hotspots in the world. The implementation of auxiliary diagnosis support algorithm for medical text data faces challenges with interpretability and creditability. The improvement of clinical diagnostic techniques means not only the improvement of diagnostic accuracy but also the further study of diagnostic basis. Traditional research methods for diagnostic markers often require a large amount of time and economic costs. Research objects are often dozens of samples, and it is, therefore, difficult to synthesize large amounts of data. Therefore, the comprehensiveness and reliability of traditional methods have yet to be improved. Therefore, the establishment of a model that can automatically diagnose diseases and automatically provide a diagnostic basis at the same time has a positive effect on the improvement of medical diagnostic techniques. METHODS: Here, we established an auxiliary diagnostic tool based on attention deep learning algorithm to diagnostic hyperlipemia and automatically predict the corresponding diagnostic markers using hematological parameters. In this paper, we not only demonstrated the ability of the proposed model to automatically diagnose diseases using text-based medical data, such as physiological parameters, but also demonstrated its ability to forecast disease diagnostic markers. Human physiological parameters are used as input to the model, and the doctor’s diagnosis results as an output. Through the attention layer, the degree of attention of the model to different physiological parameters can be obtained, that is, the model provides a diagnostic basis. RESULTS: It achieved 94% ACC, 97.48% AUC, 96% sensitivity and 92% specificity with the test dataset. All the above samples are drawn from clinical practice. Moreover, the model predicted the diagnostic markers of hyperlipidemia by the attention mechanism, and the results were fully agreeable to the golden criteria. DISCUSSION: The auxiliary diagnosis system proposed in this paper not only achieves the accurate and robust performance, and can be used for the preliminary diagnosis of patients, but also showing its great potential to discover new diagnostic markers. Therefore, it not only can improve the efficiency of clinical diagnosis but also shorten the research period of researching a diagnosis basis to an extent. It has a positive significance to the development of the medical diagnosis level.
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spelling pubmed-70734422020-03-24 Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically Liu, Yuliang Zhang, Quan Zhao, Geng Liu, Guohua Liu, Zhiang Diabetes Metab Syndr Obes Original Research INTRODUCTION: The research of auxiliary diagnosis has always been one of the hotspots in the world. The implementation of auxiliary diagnosis support algorithm for medical text data faces challenges with interpretability and creditability. The improvement of clinical diagnostic techniques means not only the improvement of diagnostic accuracy but also the further study of diagnostic basis. Traditional research methods for diagnostic markers often require a large amount of time and economic costs. Research objects are often dozens of samples, and it is, therefore, difficult to synthesize large amounts of data. Therefore, the comprehensiveness and reliability of traditional methods have yet to be improved. Therefore, the establishment of a model that can automatically diagnose diseases and automatically provide a diagnostic basis at the same time has a positive effect on the improvement of medical diagnostic techniques. METHODS: Here, we established an auxiliary diagnostic tool based on attention deep learning algorithm to diagnostic hyperlipemia and automatically predict the corresponding diagnostic markers using hematological parameters. In this paper, we not only demonstrated the ability of the proposed model to automatically diagnose diseases using text-based medical data, such as physiological parameters, but also demonstrated its ability to forecast disease diagnostic markers. Human physiological parameters are used as input to the model, and the doctor’s diagnosis results as an output. Through the attention layer, the degree of attention of the model to different physiological parameters can be obtained, that is, the model provides a diagnostic basis. RESULTS: It achieved 94% ACC, 97.48% AUC, 96% sensitivity and 92% specificity with the test dataset. All the above samples are drawn from clinical practice. Moreover, the model predicted the diagnostic markers of hyperlipidemia by the attention mechanism, and the results were fully agreeable to the golden criteria. DISCUSSION: The auxiliary diagnosis system proposed in this paper not only achieves the accurate and robust performance, and can be used for the preliminary diagnosis of patients, but also showing its great potential to discover new diagnostic markers. Therefore, it not only can improve the efficiency of clinical diagnosis but also shorten the research period of researching a diagnosis basis to an extent. It has a positive significance to the development of the medical diagnosis level. Dove 2020-03-11 /pmc/articles/PMC7073442/ /pubmed/32210601 http://dx.doi.org/10.2147/DMSO.S242585 Text en © 2020 Liu et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Liu, Yuliang
Zhang, Quan
Zhao, Geng
Liu, Guohua
Liu, Zhiang
Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically
title Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically
title_full Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically
title_fullStr Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically
title_full_unstemmed Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically
title_short Deep Learning-Based Method of Diagnosing Hyperlipidemia and Providing Diagnostic Markers Automatically
title_sort deep learning-based method of diagnosing hyperlipidemia and providing diagnostic markers automatically
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073442/
https://www.ncbi.nlm.nih.gov/pubmed/32210601
http://dx.doi.org/10.2147/DMSO.S242585
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