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Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae
Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I–Q (1–9) and cytosporins O–W (15–23), together with eight known analogs (10–14 and 24–26). The structures of the new compo...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073511/ https://www.ncbi.nlm.nih.gov/pubmed/32102178 http://dx.doi.org/10.3390/md18020129 |
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author | Yu, Xiaoqin Müller, Werner E. G. Meier, Dieter Kalscheuer, Rainer Guo, Zhiyong Zou, Kun Umeokoli, Blessing O. Liu, Zhen Proksch, Peter |
author_facet | Yu, Xiaoqin Müller, Werner E. G. Meier, Dieter Kalscheuer, Rainer Guo, Zhiyong Zou, Kun Umeokoli, Blessing O. Liu, Zhen Proksch, Peter |
author_sort | Yu, Xiaoqin |
collection | PubMed |
description | Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I–Q (1–9) and cytosporins O–W (15–23), together with eight known analogs (10–14 and 24–26). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher’s method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC(50) value of 3.0 μM. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations. |
format | Online Article Text |
id | pubmed-7073511 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70735112020-03-20 Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae Yu, Xiaoqin Müller, Werner E. G. Meier, Dieter Kalscheuer, Rainer Guo, Zhiyong Zou, Kun Umeokoli, Blessing O. Liu, Zhen Proksch, Peter Mar Drugs Article Chemical investigation of secondary metabolites from the endophytic fungus Pseudopestalotiopsis theae led to the isolation of eighteen new polyketide derivatives, pestalotheols I–Q (1–9) and cytosporins O–W (15–23), together with eight known analogs (10–14 and 24–26). The structures of the new compounds were elucidated by HRMS and 1D and 2D NMR data, as well as by comparison with literature data. Modified Mosher’s method was applied to determine the absolute configuration of some compounds. Compound 23 showed significant cytotoxicity against the mouse lymphoma cell line L5178Y with an IC(50) value of 3.0 μM. Furthermore, compounds 22 and 23 showed moderate antibacterial activity against drug-resistant Acinetobacter baumannii (ATCC BAA-1605) in combination with sublethal colistin concentrations. MDPI 2020-02-23 /pmc/articles/PMC7073511/ /pubmed/32102178 http://dx.doi.org/10.3390/md18020129 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Yu, Xiaoqin Müller, Werner E. G. Meier, Dieter Kalscheuer, Rainer Guo, Zhiyong Zou, Kun Umeokoli, Blessing O. Liu, Zhen Proksch, Peter Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae |
title | Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae |
title_full | Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae |
title_fullStr | Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae |
title_full_unstemmed | Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae |
title_short | Polyketide Derivatives from Mangrove Derived Endophytic Fungus Pseudopestalotiopsis theae |
title_sort | polyketide derivatives from mangrove derived endophytic fungus pseudopestalotiopsis theae |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073511/ https://www.ncbi.nlm.nih.gov/pubmed/32102178 http://dx.doi.org/10.3390/md18020129 |
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