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Form from Function, Order from Chaos in Male Germline Chromatin
Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073629/ https://www.ncbi.nlm.nih.gov/pubmed/32085642 http://dx.doi.org/10.3390/genes11020210 |
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author | Ellis, Peter J. I. Griffin, Darren K. |
author_facet | Ellis, Peter J. I. Griffin, Darren K. |
author_sort | Ellis, Peter J. I. |
collection | PubMed |
description | Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts. |
format | Online Article Text |
id | pubmed-7073629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70736292020-03-19 Form from Function, Order from Chaos in Male Germline Chromatin Ellis, Peter J. I. Griffin, Darren K. Genes (Basel) Editorial Spermatogenesis requires radical restructuring of germline chromatin at multiple stages, involving co-ordinated waves of DNA methylation and demethylation, histone modification, replacement and removal occurring before, during and after meiosis. This Special Issue has drawn together papers addressing many aspects of chromatin organization and dynamics in the male germ line, in humans and in model organisms. Two major themes emerge from these studies: the first is the functional significance of nuclear organisation in the developing germline; the second is the interplay between sperm chromatin structure and susceptibility to DNA damage and mutation. The consequences of these aspects for fertility, both in humans and other animals, is a major health and social welfare issue and this is reflected in these nine exciting manuscripts. MDPI 2020-02-18 /pmc/articles/PMC7073629/ /pubmed/32085642 http://dx.doi.org/10.3390/genes11020210 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Editorial Ellis, Peter J. I. Griffin, Darren K. Form from Function, Order from Chaos in Male Germline Chromatin |
title | Form from Function, Order from Chaos in Male Germline Chromatin |
title_full | Form from Function, Order from Chaos in Male Germline Chromatin |
title_fullStr | Form from Function, Order from Chaos in Male Germline Chromatin |
title_full_unstemmed | Form from Function, Order from Chaos in Male Germline Chromatin |
title_short | Form from Function, Order from Chaos in Male Germline Chromatin |
title_sort | form from function, order from chaos in male germline chromatin |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073629/ https://www.ncbi.nlm.nih.gov/pubmed/32085642 http://dx.doi.org/10.3390/genes11020210 |
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