Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272

Three new polyketides, ketidocillinones A–C (1–3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using EC...

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Autores principales: Shah, Mudassir, Sun, Chunxiao, Sun, Zichao, Zhang, Guojian, Che, Qian, Gu, Qianqun, Zhu, Tianjiao, Li, Dehai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073682/
https://www.ncbi.nlm.nih.gov/pubmed/31979231
http://dx.doi.org/10.3390/md18020071
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author Shah, Mudassir
Sun, Chunxiao
Sun, Zichao
Zhang, Guojian
Che, Qian
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
author_facet Shah, Mudassir
Sun, Chunxiao
Sun, Zichao
Zhang, Guojian
Che, Qian
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
author_sort Shah, Mudassir
collection PubMed
description Three new polyketides, ketidocillinones A–C (1–3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1−3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL.
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spelling pubmed-70736822020-03-19 Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272 Shah, Mudassir Sun, Chunxiao Sun, Zichao Zhang, Guojian Che, Qian Gu, Qianqun Zhu, Tianjiao Li, Dehai Mar Drugs Article Three new polyketides, ketidocillinones A–C (1–3), were discovered from the extract of an Antarctica sponge-derived fungus Penicillium sp. HDN151272. All the structures were deduced by spectroscopic data, including NMR and HRESIMS. The absolute configuration of compound 3 was established by using ECD calculation. Compounds 1−3 can be slowly oxidized to quinone form when exposed to air. Ketidocillinones B and C (2 and 3) exhibited potent antibacterial activity against Pseudomonas aeurigenosa, Mycobacterium phlei, and MRCNS (methicillin-resistant coagulase-negative staphylococci) with MIC values ranging from 1.56 to 25.00 µg/mL. MDPI 2020-01-23 /pmc/articles/PMC7073682/ /pubmed/31979231 http://dx.doi.org/10.3390/md18020071 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Shah, Mudassir
Sun, Chunxiao
Sun, Zichao
Zhang, Guojian
Che, Qian
Gu, Qianqun
Zhu, Tianjiao
Li, Dehai
Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
title Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
title_full Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
title_fullStr Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
title_full_unstemmed Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
title_short Antibacterial Polyketides from Antarctica Sponge-Derived Fungus Penicillium sp. HDN151272
title_sort antibacterial polyketides from antarctica sponge-derived fungus penicillium sp. hdn151272
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073682/
https://www.ncbi.nlm.nih.gov/pubmed/31979231
http://dx.doi.org/10.3390/md18020071
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