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Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation

Under normal conditions, the cornea, being the transparent “windscreen” of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting factors, which leads to ingrowth of blood and lympha...

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Autores principales: Clahsen, Thomas, Büttner, Christian, Hatami, Niloofar, Reis, André, Cursiefen, Claus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073692/
https://www.ncbi.nlm.nih.gov/pubmed/32050484
http://dx.doi.org/10.3390/jcm9020479
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author Clahsen, Thomas
Büttner, Christian
Hatami, Niloofar
Reis, André
Cursiefen, Claus
author_facet Clahsen, Thomas
Büttner, Christian
Hatami, Niloofar
Reis, André
Cursiefen, Claus
author_sort Clahsen, Thomas
collection PubMed
description Under normal conditions, the cornea, being the transparent “windscreen” of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting factors, which leads to ingrowth of blood and lymphatic vessels. The newly formed lymphatic vessels increase the risk of graft rejection after subsequent corneal transplantation. Corneal transplantation is one of the most commonly performed transplantations worldwide, with more than 40,000 surgeries per year in Europe. To date, various anti-hem- and anti-lymphangiogenic treatment strategies have been developed specifically for the corneal vascular endothelial growth factor (VEGF) pathway. Currently, however, no treatment strategies are clinically available to specifically modulate lymphangiogenesis. In this review, we will give an overview about endogenous regulators of hem- and lymphangiogenesis and discuss potential new strategies for targeting pathological lymphangiogenesis. Furthermore, we will review recently identified modulators and demonstrate that the cornea is a suitable model for the identification of novel endogenous modulators of lymphangiogenesis. The identification of novel modulators of lymphangiogenesis and a better understanding of the signaling pathways involved will contribute to the development of new therapeutic targets for the treatment of pathological lymphangiogenesis. This, in turn, will improve graft rejection, not only for the cornea.
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spelling pubmed-70736922020-03-19 Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation Clahsen, Thomas Büttner, Christian Hatami, Niloofar Reis, André Cursiefen, Claus J Clin Med Review Under normal conditions, the cornea, being the transparent “windscreen” of the eye, is free of both blood and lymphatic vessels. However, various diseases of the eye, like infections, can interfere with the balance between promoting and inhibiting factors, which leads to ingrowth of blood and lymphatic vessels. The newly formed lymphatic vessels increase the risk of graft rejection after subsequent corneal transplantation. Corneal transplantation is one of the most commonly performed transplantations worldwide, with more than 40,000 surgeries per year in Europe. To date, various anti-hem- and anti-lymphangiogenic treatment strategies have been developed specifically for the corneal vascular endothelial growth factor (VEGF) pathway. Currently, however, no treatment strategies are clinically available to specifically modulate lymphangiogenesis. In this review, we will give an overview about endogenous regulators of hem- and lymphangiogenesis and discuss potential new strategies for targeting pathological lymphangiogenesis. Furthermore, we will review recently identified modulators and demonstrate that the cornea is a suitable model for the identification of novel endogenous modulators of lymphangiogenesis. The identification of novel modulators of lymphangiogenesis and a better understanding of the signaling pathways involved will contribute to the development of new therapeutic targets for the treatment of pathological lymphangiogenesis. This, in turn, will improve graft rejection, not only for the cornea. MDPI 2020-02-09 /pmc/articles/PMC7073692/ /pubmed/32050484 http://dx.doi.org/10.3390/jcm9020479 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Clahsen, Thomas
Büttner, Christian
Hatami, Niloofar
Reis, André
Cursiefen, Claus
Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
title Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
title_full Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
title_fullStr Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
title_full_unstemmed Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
title_short Role of Endogenous Regulators of Hem- And Lymphangiogenesis in Corneal Transplantation
title_sort role of endogenous regulators of hem- and lymphangiogenesis in corneal transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073692/
https://www.ncbi.nlm.nih.gov/pubmed/32050484
http://dx.doi.org/10.3390/jcm9020479
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