RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription

RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It...

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Autores principales: Andrs, Martin, Hasanova, Zdenka, Oravetzova, Anna, Dobrovolna, Jana, Janscak, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073763/
https://www.ncbi.nlm.nih.gov/pubmed/32098287
http://dx.doi.org/10.3390/genes11020232
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author Andrs, Martin
Hasanova, Zdenka
Oravetzova, Anna
Dobrovolna, Jana
Janscak, Pavel
author_facet Andrs, Martin
Hasanova, Zdenka
Oravetzova, Anna
Dobrovolna, Jana
Janscak, Pavel
author_sort Andrs, Martin
collection PubMed
description RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development.
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spelling pubmed-70737632020-03-19 RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription Andrs, Martin Hasanova, Zdenka Oravetzova, Anna Dobrovolna, Jana Janscak, Pavel Genes (Basel) Review RECQ5 belongs to the RecQ family of DNA helicases. It is conserved from Drosophila to humans and its deficiency results in genomic instability and cancer susceptibility in mice. Human RECQ5 is known for its ability to regulate homologous recombination by disrupting RAD51 nucleoprotein filaments. It also binds to RNA polymerase II (RNAPII) and negatively regulates transcript elongation by RNAPII. Here, we summarize recent studies implicating RECQ5 in the prevention and resolution of transcription-replication conflicts, a major intrinsic source of genomic instability during cancer development. MDPI 2020-02-21 /pmc/articles/PMC7073763/ /pubmed/32098287 http://dx.doi.org/10.3390/genes11020232 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Andrs, Martin
Hasanova, Zdenka
Oravetzova, Anna
Dobrovolna, Jana
Janscak, Pavel
RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
title RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
title_full RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
title_fullStr RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
title_full_unstemmed RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
title_short RECQ5: A Mysterious Helicase at the Interface of DNA Replication and Transcription
title_sort recq5: a mysterious helicase at the interface of dna replication and transcription
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073763/
https://www.ncbi.nlm.nih.gov/pubmed/32098287
http://dx.doi.org/10.3390/genes11020232
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