Cargando…

Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study

Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by imm...

Descripción completa

Detalles Bibliográficos
Autores principales: Lee, Yi-Ju, Chan, Lung, Yeh, Chung-Min, Lee, Chien-Hsun, Sung, Wen-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073896/
https://www.ncbi.nlm.nih.gov/pubmed/32019121
http://dx.doi.org/10.3390/medicina56020057
_version_ 1783506718091640832
author Lee, Yi-Ju
Chan, Lung
Yeh, Chung-Min
Lee, Chien-Hsun
Sung, Wen-Wei
author_facet Lee, Yi-Ju
Chan, Lung
Yeh, Chung-Min
Lee, Chien-Hsun
Sung, Wen-Wei
author_sort Lee, Yi-Ju
collection PubMed
description Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan–Meier analysis and Cox proportional hazard models. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034–2.191, p = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low T-value. Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value.
format Online
Article
Text
id pubmed-7073896
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-70738962020-03-19 Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study Lee, Yi-Ju Chan, Lung Yeh, Chung-Min Lee, Chien-Hsun Sung, Wen-Wei Medicina (Kaunas) Article Background and Objectives: Patients with oral squamous cell carcinoma (OSCC), a common malignancy in Asian countries, have a poor prognosis. We investigated the role of Krüppel-like factor 17 (KLF17) and its prognostic significance in OSCC. Materials and Methods: KLF17 expression was measured by immunohistochemical staining of specimens from 283 patients with OSCC. We analyzed correlations between KLF17 expression and clinicopathologic features and between KLF17 expression and overall survival. The prognostic value of KLF17 was tested using Kaplan–Meier analysis and Cox proportional hazard models. Results: Among the 283 patients, high KLF17 expression was significantly associated with an early OSCC stage and low T-value (p = 0.033 and p = 0.036, respectively). The five-year survival rates were better in patients with high KLF17 expression than with low expression (66.5% and 49.6%, respectively). The prognostic role of KLF17 was further confirmed through multivariate analysis (hazard ratio 1.506, 95% confidence interval 1.034–2.191, p = 0.033). The prognostic value was more significant in patients with a history of betel quid chewing or with a low T-value. Conclusions: High KLF17 expression can serve as a marker for a favorable prognosis in patients with OSCC. The prognostic role of KLF17 is more significant in patients with a history of betel quid chewing or a low T-value. MDPI 2020-01-30 /pmc/articles/PMC7073896/ /pubmed/32019121 http://dx.doi.org/10.3390/medicina56020057 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Yi-Ju
Chan, Lung
Yeh, Chung-Min
Lee, Chien-Hsun
Sung, Wen-Wei
Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
title Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
title_full Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
title_fullStr Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
title_full_unstemmed Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
title_short Overexpression of KLF17 Predicts a Favorable Prognosis in Patients with Oral Squamous Cell Carcinoma: A Retrospective Study
title_sort overexpression of klf17 predicts a favorable prognosis in patients with oral squamous cell carcinoma: a retrospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073896/
https://www.ncbi.nlm.nih.gov/pubmed/32019121
http://dx.doi.org/10.3390/medicina56020057
work_keys_str_mv AT leeyiju overexpressionofklf17predictsafavorableprognosisinpatientswithoralsquamouscellcarcinomaaretrospectivestudy
AT chanlung overexpressionofklf17predictsafavorableprognosisinpatientswithoralsquamouscellcarcinomaaretrospectivestudy
AT yehchungmin overexpressionofklf17predictsafavorableprognosisinpatientswithoralsquamouscellcarcinomaaretrospectivestudy
AT leechienhsun overexpressionofklf17predictsafavorableprognosisinpatientswithoralsquamouscellcarcinomaaretrospectivestudy
AT sungwenwei overexpressionofklf17predictsafavorableprognosisinpatientswithoralsquamouscellcarcinomaaretrospectivestudy