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Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline

Despite the prevalence of male factor infertility, most cases are defined as idiopathic, thus limiting treatment options and driving increased rates of recourse to assisted reproductive technologies (ARTs). Regrettably, our current armory of ARTs does not constitute therapeutic treatments for male i...

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Detalles Bibliográficos
Autores principales: Walters, Jessica L.H., Gadella, Bart M., Sutherland, Jessie M., Nixon, Brett, Bromfield, Elizabeth G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073900/
https://www.ncbi.nlm.nih.gov/pubmed/31979378
http://dx.doi.org/10.3390/jcm9020327
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author Walters, Jessica L.H.
Gadella, Bart M.
Sutherland, Jessie M.
Nixon, Brett
Bromfield, Elizabeth G.
author_facet Walters, Jessica L.H.
Gadella, Bart M.
Sutherland, Jessie M.
Nixon, Brett
Bromfield, Elizabeth G.
author_sort Walters, Jessica L.H.
collection PubMed
description Despite the prevalence of male factor infertility, most cases are defined as idiopathic, thus limiting treatment options and driving increased rates of recourse to assisted reproductive technologies (ARTs). Regrettably, our current armory of ARTs does not constitute therapeutic treatments for male infertility, thus highlighting an urgent need for novel intervention strategies. In our attempts to fill this void, we have come to appreciate that the production of pathological levels of oxygen radicals within the male germline are a defining etiology of many idiopathic infertility cases. Indeed, an imbalance of reactive oxygen species can precipitate a cascade of deleterious sequelae, beginning with the peroxidation of membrane lipids and culminating in cellular dysfunction and death. Here, we shine light on the importance of lipid homeostasis, and the impact of lipid stress in the demise of the male germ cell. We also seek to highlight the utility of emerging lipidomic technologies to enhance our understanding of the diverse roles that lipids play in sperm function, and to identify biomarkers capable of tracking infertility in patient cohorts. Such information should improve our fundamental understanding of the mechanistic causes of male infertility and find application in the development of efficacious treatment options.
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spelling pubmed-70739002020-03-19 Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline Walters, Jessica L.H. Gadella, Bart M. Sutherland, Jessie M. Nixon, Brett Bromfield, Elizabeth G. J Clin Med Review Despite the prevalence of male factor infertility, most cases are defined as idiopathic, thus limiting treatment options and driving increased rates of recourse to assisted reproductive technologies (ARTs). Regrettably, our current armory of ARTs does not constitute therapeutic treatments for male infertility, thus highlighting an urgent need for novel intervention strategies. In our attempts to fill this void, we have come to appreciate that the production of pathological levels of oxygen radicals within the male germline are a defining etiology of many idiopathic infertility cases. Indeed, an imbalance of reactive oxygen species can precipitate a cascade of deleterious sequelae, beginning with the peroxidation of membrane lipids and culminating in cellular dysfunction and death. Here, we shine light on the importance of lipid homeostasis, and the impact of lipid stress in the demise of the male germ cell. We also seek to highlight the utility of emerging lipidomic technologies to enhance our understanding of the diverse roles that lipids play in sperm function, and to identify biomarkers capable of tracking infertility in patient cohorts. Such information should improve our fundamental understanding of the mechanistic causes of male infertility and find application in the development of efficacious treatment options. MDPI 2020-01-23 /pmc/articles/PMC7073900/ /pubmed/31979378 http://dx.doi.org/10.3390/jcm9020327 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Walters, Jessica L.H.
Gadella, Bart M.
Sutherland, Jessie M.
Nixon, Brett
Bromfield, Elizabeth G.
Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
title Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
title_full Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
title_fullStr Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
title_full_unstemmed Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
title_short Male Infertility: Shining a Light on Lipids and Lipid-Modulating Enzymes in the Male Germline
title_sort male infertility: shining a light on lipids and lipid-modulating enzymes in the male germline
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073900/
https://www.ncbi.nlm.nih.gov/pubmed/31979378
http://dx.doi.org/10.3390/jcm9020327
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