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Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study

The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries. However, their design did not allow for the adjustment for other conditions associated with elevated B12. The objectives of this study were to confirm this association af...

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Autores principales: Urbanski, Geoffrey, Hamel, Jean-François, Prouveur, Benoît, Annweiler, Cédric, Ghali, Alaa, Cassereau, Julien, Lozac’h, Pierre, Lavigne, Christian, Lacombe, Valentin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073937/
https://www.ncbi.nlm.nih.gov/pubmed/32050436
http://dx.doi.org/10.3390/jcm9020474
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author Urbanski, Geoffrey
Hamel, Jean-François
Prouveur, Benoît
Annweiler, Cédric
Ghali, Alaa
Cassereau, Julien
Lozac’h, Pierre
Lavigne, Christian
Lacombe, Valentin
author_facet Urbanski, Geoffrey
Hamel, Jean-François
Prouveur, Benoît
Annweiler, Cédric
Ghali, Alaa
Cassereau, Julien
Lozac’h, Pierre
Lavigne, Christian
Lacombe, Valentin
author_sort Urbanski, Geoffrey
collection PubMed
description The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries. However, their design did not allow for the adjustment for other conditions associated with elevated B12. The objectives of this study were to confirm this association after the adjustment for all causes of elevated B12, and to study the variations according to the increasing B12 level, the type of cancers, and the presence of metastases. We compared 785 patients with B12 ≥ 1000 ng/L with 785 controls matched for sex and age with B12 < 1000 ng/L. Analyses were adjusted for the causes of elevated B12: myeloid blood malignancies, acute or chronic liver diseases, chronic kidney failure, autoimmune or inflammatory diseases, and excessive B12 supplementation. A B12 ≥ 1000 ng/L was associated with the presence of solid cancer without metastases (OR 1.96 [95%CI: 1.18 to 3.25]) and with metastases (OR 4.21 [95%CI: 2.67 to 6.64]) after adjustment for all elevated B12-related causes. The strength of the association rose with the increasing B12 level, in particular in cases of metastases. No association between liver cancers and elevated B12 level was found after adjustment for chronic liver diseases. In conclusion, unexplained elevated B12 levels should be examined as a possible marker of solid cancer.
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spelling pubmed-70739372020-03-19 Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study Urbanski, Geoffrey Hamel, Jean-François Prouveur, Benoît Annweiler, Cédric Ghali, Alaa Cassereau, Julien Lozac’h, Pierre Lavigne, Christian Lacombe, Valentin J Clin Med Article The association between elevated plasma vitamin B12 (B12) level and solid cancers has been documented by two national registries. However, their design did not allow for the adjustment for other conditions associated with elevated B12. The objectives of this study were to confirm this association after the adjustment for all causes of elevated B12, and to study the variations according to the increasing B12 level, the type of cancers, and the presence of metastases. We compared 785 patients with B12 ≥ 1000 ng/L with 785 controls matched for sex and age with B12 < 1000 ng/L. Analyses were adjusted for the causes of elevated B12: myeloid blood malignancies, acute or chronic liver diseases, chronic kidney failure, autoimmune or inflammatory diseases, and excessive B12 supplementation. A B12 ≥ 1000 ng/L was associated with the presence of solid cancer without metastases (OR 1.96 [95%CI: 1.18 to 3.25]) and with metastases (OR 4.21 [95%CI: 2.67 to 6.64]) after adjustment for all elevated B12-related causes. The strength of the association rose with the increasing B12 level, in particular in cases of metastases. No association between liver cancers and elevated B12 level was found after adjustment for chronic liver diseases. In conclusion, unexplained elevated B12 levels should be examined as a possible marker of solid cancer. MDPI 2020-02-09 /pmc/articles/PMC7073937/ /pubmed/32050436 http://dx.doi.org/10.3390/jcm9020474 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urbanski, Geoffrey
Hamel, Jean-François
Prouveur, Benoît
Annweiler, Cédric
Ghali, Alaa
Cassereau, Julien
Lozac’h, Pierre
Lavigne, Christian
Lacombe, Valentin
Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study
title Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study
title_full Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study
title_fullStr Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study
title_full_unstemmed Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study
title_short Strength of the Association of Elevated Vitamin B12 and Solid Cancers: An Adjusted Case-Control Study
title_sort strength of the association of elevated vitamin b12 and solid cancers: an adjusted case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7073937/
https://www.ncbi.nlm.nih.gov/pubmed/32050436
http://dx.doi.org/10.3390/jcm9020474
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