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New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074288/ https://www.ncbi.nlm.nih.gov/pubmed/32012770 http://dx.doi.org/10.3390/md18020084 |
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author | Gutiérrez, Marcelino Santamaría, Ricardo Gómez-Reyes, José Félix Guzmán, Héctor M. Ávila-Román, Javier Motilva, Virginia Talero, Elena |
author_facet | Gutiérrez, Marcelino Santamaría, Ricardo Gómez-Reyes, José Félix Guzmán, Héctor M. Ávila-Román, Javier Motilva, Virginia Talero, Elena |
author_sort | Gutiérrez, Marcelino |
collection | PubMed |
description | Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases. |
format | Online Article Text |
id | pubmed-7074288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70742882020-03-19 New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum Gutiérrez, Marcelino Santamaría, Ricardo Gómez-Reyes, José Félix Guzmán, Héctor M. Ávila-Román, Javier Motilva, Virginia Talero, Elena Mar Drugs Article Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases. MDPI 2020-01-27 /pmc/articles/PMC7074288/ /pubmed/32012770 http://dx.doi.org/10.3390/md18020084 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Gutiérrez, Marcelino Santamaría, Ricardo Gómez-Reyes, José Félix Guzmán, Héctor M. Ávila-Román, Javier Motilva, Virginia Talero, Elena New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum |
title | New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum |
title_full | New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum |
title_fullStr | New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum |
title_full_unstemmed | New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum |
title_short | New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum |
title_sort | new eunicellin-type diterpenes from the panamanian octocoral briareum asbestinum |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074288/ https://www.ncbi.nlm.nih.gov/pubmed/32012770 http://dx.doi.org/10.3390/md18020084 |
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