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New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum

Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the...

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Autores principales: Gutiérrez, Marcelino, Santamaría, Ricardo, Gómez-Reyes, José Félix, Guzmán, Héctor M., Ávila-Román, Javier, Motilva, Virginia, Talero, Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074288/
https://www.ncbi.nlm.nih.gov/pubmed/32012770
http://dx.doi.org/10.3390/md18020084
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author Gutiérrez, Marcelino
Santamaría, Ricardo
Gómez-Reyes, José Félix
Guzmán, Héctor M.
Ávila-Román, Javier
Motilva, Virginia
Talero, Elena
author_facet Gutiérrez, Marcelino
Santamaría, Ricardo
Gómez-Reyes, José Félix
Guzmán, Héctor M.
Ávila-Román, Javier
Motilva, Virginia
Talero, Elena
author_sort Gutiérrez, Marcelino
collection PubMed
description Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases.
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spelling pubmed-70742882020-03-19 New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum Gutiérrez, Marcelino Santamaría, Ricardo Gómez-Reyes, José Félix Guzmán, Héctor M. Ávila-Román, Javier Motilva, Virginia Talero, Elena Mar Drugs Article Gorgonian octocorals are considered a prolific source of secondary metabolites with a wide range of biological activities, including anti-inflammatory activity. In particular, the genus Briareum is known for producing a wealth of diterpenes with complex chemical structures. The chemical study of the methanolic extract of Briareum asbestinum collected in Bocas del Toro, on the Caribbean side of Panama, led to the isolation of three new eunicellin-type diterpenes: briarellin T (1), asbestinin 27 (2), asbestinin 28 (3) and the previously described asbestinin 17 (4). The structures of the new compounds were determined by extensive NMR analyses and HRMS. Anti-inflammatory activity assays showed a significant reduction of the pro-inflammatory cytokines TNF-α, IL-6, IL-1β and IL-8 as well as a downregulation of COX-2 expression in LPS-stimulated THP-1 macrophages. These findings support the potential use of these marine compounds as therapeutic agents in the treatment of inflammatory diseases. MDPI 2020-01-27 /pmc/articles/PMC7074288/ /pubmed/32012770 http://dx.doi.org/10.3390/md18020084 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gutiérrez, Marcelino
Santamaría, Ricardo
Gómez-Reyes, José Félix
Guzmán, Héctor M.
Ávila-Román, Javier
Motilva, Virginia
Talero, Elena
New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
title New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
title_full New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
title_fullStr New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
title_full_unstemmed New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
title_short New Eunicellin-Type Diterpenes from the Panamanian Octocoral Briareum asbestinum
title_sort new eunicellin-type diterpenes from the panamanian octocoral briareum asbestinum
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074288/
https://www.ncbi.nlm.nih.gov/pubmed/32012770
http://dx.doi.org/10.3390/md18020084
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