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Inflammatory Targets in Diabetic Nephropathy

One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies ar...

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Autores principales: Donate-Correa, Javier, Luis-Rodríguez, Desirée, Martín-Núñez, Ernesto, Tagua, Víctor G., Hernández-Carballo, Carolina, Ferri, Carla, Rodríguez-Rodríguez, Ana Elena, Mora-Fernández, Carmen, Navarro-González, Juan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074396/
https://www.ncbi.nlm.nih.gov/pubmed/32046074
http://dx.doi.org/10.3390/jcm9020458
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author Donate-Correa, Javier
Luis-Rodríguez, Desirée
Martín-Núñez, Ernesto
Tagua, Víctor G.
Hernández-Carballo, Carolina
Ferri, Carla
Rodríguez-Rodríguez, Ana Elena
Mora-Fernández, Carmen
Navarro-González, Juan F.
author_facet Donate-Correa, Javier
Luis-Rodríguez, Desirée
Martín-Núñez, Ernesto
Tagua, Víctor G.
Hernández-Carballo, Carolina
Ferri, Carla
Rodríguez-Rodríguez, Ana Elena
Mora-Fernández, Carmen
Navarro-González, Juan F.
author_sort Donate-Correa, Javier
collection PubMed
description One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies are required to delay the development and the progression of this pathology. This new approach should look beyond the control of traditional risk factors such as hyperglycemia and hypertension. Currently, inflammation has been recognized as one of the underlying processes involved in the development and progression of kidney disease in the diabetic population. Understanding the cascade of signals and mechanisms that trigger this maladaptive immune response, which eventually leads to the development of DN, is crucial. This knowledge will allow the identification of new targets and facilitate the design of innovative therapeutic strategies. In this review, we focus on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discuss the potential utility of new strategies based on agents that target inflammation.
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spelling pubmed-70743962020-03-20 Inflammatory Targets in Diabetic Nephropathy Donate-Correa, Javier Luis-Rodríguez, Desirée Martín-Núñez, Ernesto Tagua, Víctor G. Hernández-Carballo, Carolina Ferri, Carla Rodríguez-Rodríguez, Ana Elena Mora-Fernández, Carmen Navarro-González, Juan F. J Clin Med Review One of the most frequent complications in patients with diabetes mellitus is diabetic nephropathy (DN). At present, it constitutes the first cause of end stage renal disease, and the main cause of cardiovascular morbidity and mortality in these patients. Therefore, it is clear that new strategies are required to delay the development and the progression of this pathology. This new approach should look beyond the control of traditional risk factors such as hyperglycemia and hypertension. Currently, inflammation has been recognized as one of the underlying processes involved in the development and progression of kidney disease in the diabetic population. Understanding the cascade of signals and mechanisms that trigger this maladaptive immune response, which eventually leads to the development of DN, is crucial. This knowledge will allow the identification of new targets and facilitate the design of innovative therapeutic strategies. In this review, we focus on the pathogenesis of proinflammatory molecules and mechanisms related to the development and progression of DN, and discuss the potential utility of new strategies based on agents that target inflammation. MDPI 2020-02-07 /pmc/articles/PMC7074396/ /pubmed/32046074 http://dx.doi.org/10.3390/jcm9020458 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Donate-Correa, Javier
Luis-Rodríguez, Desirée
Martín-Núñez, Ernesto
Tagua, Víctor G.
Hernández-Carballo, Carolina
Ferri, Carla
Rodríguez-Rodríguez, Ana Elena
Mora-Fernández, Carmen
Navarro-González, Juan F.
Inflammatory Targets in Diabetic Nephropathy
title Inflammatory Targets in Diabetic Nephropathy
title_full Inflammatory Targets in Diabetic Nephropathy
title_fullStr Inflammatory Targets in Diabetic Nephropathy
title_full_unstemmed Inflammatory Targets in Diabetic Nephropathy
title_short Inflammatory Targets in Diabetic Nephropathy
title_sort inflammatory targets in diabetic nephropathy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074396/
https://www.ncbi.nlm.nih.gov/pubmed/32046074
http://dx.doi.org/10.3390/jcm9020458
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