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Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease

Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence of AVC and CAC, and whether AVC was associated with all-cause mortality independent of the presence...

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Autores principales: Dai, Lu, Plunde, Oscar, Qureshi, Abdul Rashid, Lindholm, Bengt, Brismar, Torkel B., Schurgers, Leon J., Söderberg, Magnus, Ripsweden, Jonaz, Bäck, Magnus, Stenvinkel, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074421/
https://www.ncbi.nlm.nih.gov/pubmed/32102408
http://dx.doi.org/10.3390/jcm9020607
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author Dai, Lu
Plunde, Oscar
Qureshi, Abdul Rashid
Lindholm, Bengt
Brismar, Torkel B.
Schurgers, Leon J.
Söderberg, Magnus
Ripsweden, Jonaz
Bäck, Magnus
Stenvinkel, Peter
author_facet Dai, Lu
Plunde, Oscar
Qureshi, Abdul Rashid
Lindholm, Bengt
Brismar, Torkel B.
Schurgers, Leon J.
Söderberg, Magnus
Ripsweden, Jonaz
Bäck, Magnus
Stenvinkel, Peter
author_sort Dai, Lu
collection PubMed
description Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence of AVC and CAC, and whether AVC was associated with all-cause mortality independent of the presence of CAC in ESRD. Methods: 259 ESRD patients (median age 55 years, 67% males) undergoing cardiac computed tomography were included. Framingham risk score (FRS), presence of cardiovascular disease (CVD), statin use, nutritional status and other relevant laboratory data were determined at baseline. During follow-up for median 36 months, 44 patients died, and 68 patients underwent renal transplantation. Results: The baseline overlap presence of AVC and CAC was 37%. Multivariate regression analysis showed that FRS (odds ratio (OR) 2.25; 95% confidence interval (95% CI), 1.43–3.55) and CAC score (OR (95% CI), 2.18 (1.34–3.59)) were independent determinants of AVC. In competing-risk regression models adjusted for presence of CAC, inflammation, nutritional status, CVD, FRS and statin use, AVC remained independently associated with all-cause mortality (sub-hazard ratio (95% CI), 2.57 (1.20–5.51)). Conclusions: The overlap of AVC and CAC was 37% in this ESRD cohort. AVC was associated with increased all-cause mortality independent of presence of CAC, traditional risk factors and inflammation.
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spelling pubmed-70744212020-03-20 Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease Dai, Lu Plunde, Oscar Qureshi, Abdul Rashid Lindholm, Bengt Brismar, Torkel B. Schurgers, Leon J. Söderberg, Magnus Ripsweden, Jonaz Bäck, Magnus Stenvinkel, Peter J Clin Med Article Background: Aortic valve calcium (AVC) and coronary artery calcium (CAC) are common complications in end-stage renal disease (ESRD). We investigated the prognostic significance of overlapping presence of AVC and CAC, and whether AVC was associated with all-cause mortality independent of the presence of CAC in ESRD. Methods: 259 ESRD patients (median age 55 years, 67% males) undergoing cardiac computed tomography were included. Framingham risk score (FRS), presence of cardiovascular disease (CVD), statin use, nutritional status and other relevant laboratory data were determined at baseline. During follow-up for median 36 months, 44 patients died, and 68 patients underwent renal transplantation. Results: The baseline overlap presence of AVC and CAC was 37%. Multivariate regression analysis showed that FRS (odds ratio (OR) 2.25; 95% confidence interval (95% CI), 1.43–3.55) and CAC score (OR (95% CI), 2.18 (1.34–3.59)) were independent determinants of AVC. In competing-risk regression models adjusted for presence of CAC, inflammation, nutritional status, CVD, FRS and statin use, AVC remained independently associated with all-cause mortality (sub-hazard ratio (95% CI), 2.57 (1.20–5.51)). Conclusions: The overlap of AVC and CAC was 37% in this ESRD cohort. AVC was associated with increased all-cause mortality independent of presence of CAC, traditional risk factors and inflammation. MDPI 2020-02-24 /pmc/articles/PMC7074421/ /pubmed/32102408 http://dx.doi.org/10.3390/jcm9020607 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Dai, Lu
Plunde, Oscar
Qureshi, Abdul Rashid
Lindholm, Bengt
Brismar, Torkel B.
Schurgers, Leon J.
Söderberg, Magnus
Ripsweden, Jonaz
Bäck, Magnus
Stenvinkel, Peter
Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
title Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
title_full Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
title_fullStr Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
title_full_unstemmed Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
title_short Aortic Valve Calcium Associates with All-Cause Mortality Independent of Coronary Artery Calcium and Inflammation in Patients with End-Stage Renal Disease
title_sort aortic valve calcium associates with all-cause mortality independent of coronary artery calcium and inflammation in patients with end-stage renal disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074421/
https://www.ncbi.nlm.nih.gov/pubmed/32102408
http://dx.doi.org/10.3390/jcm9020607
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