Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension

Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 0...

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Autores principales: Richter, Manuel J., Harutyunova, Satenik, Bollmann, Tom, Classen, Simon, Fuge, Jan, Gall, Henning, Gerhardt, Felix, Ghofrani, Hossein A., Gunkel, Hartmut, Grünig, Ekkehard, Halank, Michael, Heine, Alexander, Klose, Hans, Lange, Tobias J., Neurohr, Claus, Nickolaus, Kai, Opitz, Christian F., Rosenkranz, Stephan, Seyfarth, Hans-Jürgen, Tello, Khodr, Ewert, Ralf, Olsson, Karen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074510/
https://www.ncbi.nlm.nih.gov/pubmed/32206306
http://dx.doi.org/10.1177/2045894020910136
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author Richter, Manuel J.
Harutyunova, Satenik
Bollmann, Tom
Classen, Simon
Fuge, Jan
Gall, Henning
Gerhardt, Felix
Ghofrani, Hossein A.
Gunkel, Hartmut
Grünig, Ekkehard
Halank, Michael
Heine, Alexander
Klose, Hans
Lange, Tobias J.
Neurohr, Claus
Nickolaus, Kai
Opitz, Christian F.
Rosenkranz, Stephan
Seyfarth, Hans-Jürgen
Tello, Khodr
Ewert, Ralf
Olsson, Karen M.
author_facet Richter, Manuel J.
Harutyunova, Satenik
Bollmann, Tom
Classen, Simon
Fuge, Jan
Gall, Henning
Gerhardt, Felix
Ghofrani, Hossein A.
Gunkel, Hartmut
Grünig, Ekkehard
Halank, Michael
Heine, Alexander
Klose, Hans
Lange, Tobias J.
Neurohr, Claus
Nickolaus, Kai
Opitz, Christian F.
Rosenkranz, Stephan
Seyfarth, Hans-Jürgen
Tello, Khodr
Ewert, Ralf
Olsson, Karen M.
author_sort Richter, Manuel J.
collection PubMed
description Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory.
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spelling pubmed-70745102020-03-23 Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension Richter, Manuel J. Harutyunova, Satenik Bollmann, Tom Classen, Simon Fuge, Jan Gall, Henning Gerhardt, Felix Ghofrani, Hossein A. Gunkel, Hartmut Grünig, Ekkehard Halank, Michael Heine, Alexander Klose, Hans Lange, Tobias J. Neurohr, Claus Nickolaus, Kai Opitz, Christian F. Rosenkranz, Stephan Seyfarth, Hans-Jürgen Tello, Khodr Ewert, Ralf Olsson, Karen M. Pulm Circ Research Letter Implantable infusion pumps might improve the convenience and safety of intravenous treprostinil for pulmonary arterial hypertension. The LENUS Pro® pump (approved in Europe) has a fixed flow rate. Based on 126 pumps and 2853 refills, we retrospectively analyzed the actual flow rate from 09/2010 to 09/2018. A relevant flow rate variance is evident after three years; therefore, flow rate monitoring and dose adjustment are mandatory. SAGE Publications 2020-03-13 /pmc/articles/PMC7074510/ /pubmed/32206306 http://dx.doi.org/10.1177/2045894020910136 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Letter
Richter, Manuel J.
Harutyunova, Satenik
Bollmann, Tom
Classen, Simon
Fuge, Jan
Gall, Henning
Gerhardt, Felix
Ghofrani, Hossein A.
Gunkel, Hartmut
Grünig, Ekkehard
Halank, Michael
Heine, Alexander
Klose, Hans
Lange, Tobias J.
Neurohr, Claus
Nickolaus, Kai
Opitz, Christian F.
Rosenkranz, Stephan
Seyfarth, Hans-Jürgen
Tello, Khodr
Ewert, Ralf
Olsson, Karen M.
Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
title Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
title_full Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
title_fullStr Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
title_full_unstemmed Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
title_short Flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
title_sort flow rate variance of a fully implantable pump for the delivery of intravenous treprostinil in pulmonary arterial hypertension
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074510/
https://www.ncbi.nlm.nih.gov/pubmed/32206306
http://dx.doi.org/10.1177/2045894020910136
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