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Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride

CASE SUMMARY: The present study describes the case of a feline meningioma that was detected using 5-aminolaevulinic acid hydrochloride (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence at surgery. An extra-axial mass in the temporoparietal region was observed by MRI. Following craniectomy and du...

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Autores principales: Osaki, Tomohiro, Gonda, Kengo, Murahata, Yusuke, Sunden, Yuji, Amaha, Takao, Kunisue, Narumi, Takahashi, Kiwamu, Ishizuka, Masahiro, Tanaka, Tohru, Li, Liming, Yokoe, Inoru, Yamashita, Masamichi, Azuma, Kazuo, Tsuka, Takeshi, Ito, Norihiko, Imagawa, Tomohiro, Okamoto, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074522/
https://www.ncbi.nlm.nih.gov/pubmed/32206327
http://dx.doi.org/10.1177/2055116920907429
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author Osaki, Tomohiro
Gonda, Kengo
Murahata, Yusuke
Sunden, Yuji
Amaha, Takao
Kunisue, Narumi
Takahashi, Kiwamu
Ishizuka, Masahiro
Tanaka, Tohru
Li, Liming
Yokoe, Inoru
Yamashita, Masamichi
Azuma, Kazuo
Tsuka, Takeshi
Ito, Norihiko
Imagawa, Tomohiro
Okamoto, Yoshiharu
author_facet Osaki, Tomohiro
Gonda, Kengo
Murahata, Yusuke
Sunden, Yuji
Amaha, Takao
Kunisue, Narumi
Takahashi, Kiwamu
Ishizuka, Masahiro
Tanaka, Tohru
Li, Liming
Yokoe, Inoru
Yamashita, Masamichi
Azuma, Kazuo
Tsuka, Takeshi
Ito, Norihiko
Imagawa, Tomohiro
Okamoto, Yoshiharu
author_sort Osaki, Tomohiro
collection PubMed
description CASE SUMMARY: The present study describes the case of a feline meningioma that was detected using 5-aminolaevulinic acid hydrochloride (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence at surgery. An extra-axial mass in the temporoparietal region was observed by MRI. Following craniectomy and durotomy, photodynamic detection (PDD) was performed for detection of the tumour. Intratumour PpIX was detected using fluorescence spectrum evaluation and high-performance liquid chromatography. PDD revealed bright fluorescence of PpIX induced by 5-ALA, facilitating fluorescence-guided resection of the tumour tissue. Postoperative examination demonstrated an intratumour PpIX protein concentration of 16.8 nmol/g, and based on histopathological findings we diagnosed the mass as meningioma. RELEVANCE AND NOVEL INFORMATION: PDD using 5-ALA has been used to identify the surgical margins during resection of primary human brain tumours. Recently, we have reported post-mortem PDD using 5-ALA for a canine glioblastoma. To our knowledge, this technique has not been previously used for the detection and resection of feline brain tumours. Our findings suggest that PDD using 5-ALA is useful for intraoperative fluorescence-guided resection of malignant meningioma in cats.
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spelling pubmed-70745222020-03-23 Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride Osaki, Tomohiro Gonda, Kengo Murahata, Yusuke Sunden, Yuji Amaha, Takao Kunisue, Narumi Takahashi, Kiwamu Ishizuka, Masahiro Tanaka, Tohru Li, Liming Yokoe, Inoru Yamashita, Masamichi Azuma, Kazuo Tsuka, Takeshi Ito, Norihiko Imagawa, Tomohiro Okamoto, Yoshiharu JFMS Open Rep Case Report CASE SUMMARY: The present study describes the case of a feline meningioma that was detected using 5-aminolaevulinic acid hydrochloride (5-ALA)-induced protoporphyrin IX (PpIX) fluorescence at surgery. An extra-axial mass in the temporoparietal region was observed by MRI. Following craniectomy and durotomy, photodynamic detection (PDD) was performed for detection of the tumour. Intratumour PpIX was detected using fluorescence spectrum evaluation and high-performance liquid chromatography. PDD revealed bright fluorescence of PpIX induced by 5-ALA, facilitating fluorescence-guided resection of the tumour tissue. Postoperative examination demonstrated an intratumour PpIX protein concentration of 16.8 nmol/g, and based on histopathological findings we diagnosed the mass as meningioma. RELEVANCE AND NOVEL INFORMATION: PDD using 5-ALA has been used to identify the surgical margins during resection of primary human brain tumours. Recently, we have reported post-mortem PDD using 5-ALA for a canine glioblastoma. To our knowledge, this technique has not been previously used for the detection and resection of feline brain tumours. Our findings suggest that PDD using 5-ALA is useful for intraoperative fluorescence-guided resection of malignant meningioma in cats. SAGE Publications 2020-03-13 /pmc/articles/PMC7074522/ /pubmed/32206327 http://dx.doi.org/10.1177/2055116920907429 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Osaki, Tomohiro
Gonda, Kengo
Murahata, Yusuke
Sunden, Yuji
Amaha, Takao
Kunisue, Narumi
Takahashi, Kiwamu
Ishizuka, Masahiro
Tanaka, Tohru
Li, Liming
Yokoe, Inoru
Yamashita, Masamichi
Azuma, Kazuo
Tsuka, Takeshi
Ito, Norihiko
Imagawa, Tomohiro
Okamoto, Yoshiharu
Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
title Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
title_full Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
title_fullStr Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
title_full_unstemmed Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
title_short Photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
title_sort photodynamic detection of a feline meningioma using 5-aminolaevulinic acid hydrochloride
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7074522/
https://www.ncbi.nlm.nih.gov/pubmed/32206327
http://dx.doi.org/10.1177/2055116920907429
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