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Dyslipidemia and cardiovascular disease risk among the MASHAD study population

INTRODUCTION: Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascul...

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Autores principales: Hedayatnia, Mahshad, Asadi, Zahra, Zare-Feyzabadi, Reza, Yaghooti-Khorasani, Mahdiyeh, Ghazizadeh, Hamideh, Ghaffarian-Zirak, Roshanak, Nosrati-Tirkani, Abolfazl, Mohammadi-Bajgiran, Maryam, Rohban, Mohadese, Sadabadi, Fatemeh, Rahimi, Hamid-Reza, Ghalandari, Marzieh, Ghaffari, Mohammad-Seddigh, Yousefi, Asa, Pouresmaeili, Elnaz, Besharatlou, Mohammad-Reza, Moohebati, Mohsen, Ferns, Gordon A., Esmaily, Habibollah, Ghayour-Mobarhan, Majid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075010/
https://www.ncbi.nlm.nih.gov/pubmed/32178672
http://dx.doi.org/10.1186/s12944-020-01204-y
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author Hedayatnia, Mahshad
Asadi, Zahra
Zare-Feyzabadi, Reza
Yaghooti-Khorasani, Mahdiyeh
Ghazizadeh, Hamideh
Ghaffarian-Zirak, Roshanak
Nosrati-Tirkani, Abolfazl
Mohammadi-Bajgiran, Maryam
Rohban, Mohadese
Sadabadi, Fatemeh
Rahimi, Hamid-Reza
Ghalandari, Marzieh
Ghaffari, Mohammad-Seddigh
Yousefi, Asa
Pouresmaeili, Elnaz
Besharatlou, Mohammad-Reza
Moohebati, Mohsen
Ferns, Gordon A.
Esmaily, Habibollah
Ghayour-Mobarhan, Majid
author_facet Hedayatnia, Mahshad
Asadi, Zahra
Zare-Feyzabadi, Reza
Yaghooti-Khorasani, Mahdiyeh
Ghazizadeh, Hamideh
Ghaffarian-Zirak, Roshanak
Nosrati-Tirkani, Abolfazl
Mohammadi-Bajgiran, Maryam
Rohban, Mohadese
Sadabadi, Fatemeh
Rahimi, Hamid-Reza
Ghalandari, Marzieh
Ghaffari, Mohammad-Seddigh
Yousefi, Asa
Pouresmaeili, Elnaz
Besharatlou, Mohammad-Reza
Moohebati, Mohsen
Ferns, Gordon A.
Esmaily, Habibollah
Ghayour-Mobarhan, Majid
author_sort Hedayatnia, Mahshad
collection PubMed
description INTRODUCTION: Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran. MATERIAL AND METHODS: This prospective cohort study comprised a population of 8698 men and women aged 35–65 years who were recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. Cox regression model and 95% confidence interval (CI) were used to evaluate the association of dyslipidemia and its components with CVD incidence. RESULTS: After 6 years of follow-up, 233 cases of CVD (including 119 cases of unstable angina [US], 74 cases of stable angina [SA], and 40 cases of myocardial infarction [MI]) were identified in the study population. Unadjusted baseline serum LDL-C, TC, and TG levels were positively associated with the risk of total CVD events among the entire population (HR: 1.54, 95% CI: 1.19–2; P-value< 0.01; HR: 1.53; 95% CI: 1.18–1.98; P < 0.01; HR: 1.57; 95% CI: 1.27–2.03; P < 0.01, respectively). However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12–6.57; P-value< 0.05). CONCLUSION: In the present study, TC baseline level was significantly associated with the risk of MI among men.
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spelling pubmed-70750102020-03-18 Dyslipidemia and cardiovascular disease risk among the MASHAD study population Hedayatnia, Mahshad Asadi, Zahra Zare-Feyzabadi, Reza Yaghooti-Khorasani, Mahdiyeh Ghazizadeh, Hamideh Ghaffarian-Zirak, Roshanak Nosrati-Tirkani, Abolfazl Mohammadi-Bajgiran, Maryam Rohban, Mohadese Sadabadi, Fatemeh Rahimi, Hamid-Reza Ghalandari, Marzieh Ghaffari, Mohammad-Seddigh Yousefi, Asa Pouresmaeili, Elnaz Besharatlou, Mohammad-Reza Moohebati, Mohsen Ferns, Gordon A. Esmaily, Habibollah Ghayour-Mobarhan, Majid Lipids Health Dis Research INTRODUCTION: Dyslipidemia may be defined as increased levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), or a decreased serum high-density lipoprotein cholesterol (HDL-C) concentration. Dyslipidemia is an established risk factor for cardiovascular disease (CVD). We aimed to investigate the association of dyslipidemia and CVD events among a population sample from Mashhad, in northeastern Iran. MATERIAL AND METHODS: This prospective cohort study comprised a population of 8698 men and women aged 35–65 years who were recruited from the Mashhad Stroke and Heart Atherosclerotic Disorder (MASHAD) study. Socioeconomic and demographic status, anthropometric parameters, laboratory evaluations, lifestyle factors, and medical history were gathered through a comprehensive questionnaire and laboratory and clinical assessment for all participants. Cox regression model and 95% confidence interval (CI) were used to evaluate the association of dyslipidemia and its components with CVD incidence. RESULTS: After 6 years of follow-up, 233 cases of CVD (including 119 cases of unstable angina [US], 74 cases of stable angina [SA], and 40 cases of myocardial infarction [MI]) were identified in the study population. Unadjusted baseline serum LDL-C, TC, and TG levels were positively associated with the risk of total CVD events among the entire population (HR: 1.54, 95% CI: 1.19–2; P-value< 0.01; HR: 1.53; 95% CI: 1.18–1.98; P < 0.01; HR: 1.57; 95% CI: 1.27–2.03; P < 0.01, respectively). However, after adjusting for confounding factors (age, body mass index [BMI], family history of CVD, smoking status [non-smoker, ex-smoker and current smoker], lipid lowering drug treatment, anti-hypertensive drug treatment, hypertension, healthy eating index [HEI], total energy intake, and presence of diabetes mellitus), a significant direct association only remained between TC and MI risk in men (HR: 2.71; 95%CI: 1.12–6.57; P-value< 0.05). CONCLUSION: In the present study, TC baseline level was significantly associated with the risk of MI among men. BioMed Central 2020-03-16 /pmc/articles/PMC7075010/ /pubmed/32178672 http://dx.doi.org/10.1186/s12944-020-01204-y Text en © The Author(s) 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Hedayatnia, Mahshad
Asadi, Zahra
Zare-Feyzabadi, Reza
Yaghooti-Khorasani, Mahdiyeh
Ghazizadeh, Hamideh
Ghaffarian-Zirak, Roshanak
Nosrati-Tirkani, Abolfazl
Mohammadi-Bajgiran, Maryam
Rohban, Mohadese
Sadabadi, Fatemeh
Rahimi, Hamid-Reza
Ghalandari, Marzieh
Ghaffari, Mohammad-Seddigh
Yousefi, Asa
Pouresmaeili, Elnaz
Besharatlou, Mohammad-Reza
Moohebati, Mohsen
Ferns, Gordon A.
Esmaily, Habibollah
Ghayour-Mobarhan, Majid
Dyslipidemia and cardiovascular disease risk among the MASHAD study population
title Dyslipidemia and cardiovascular disease risk among the MASHAD study population
title_full Dyslipidemia and cardiovascular disease risk among the MASHAD study population
title_fullStr Dyslipidemia and cardiovascular disease risk among the MASHAD study population
title_full_unstemmed Dyslipidemia and cardiovascular disease risk among the MASHAD study population
title_short Dyslipidemia and cardiovascular disease risk among the MASHAD study population
title_sort dyslipidemia and cardiovascular disease risk among the mashad study population
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075010/
https://www.ncbi.nlm.nih.gov/pubmed/32178672
http://dx.doi.org/10.1186/s12944-020-01204-y
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