Fanconi anemia pathway as a prospective target for cancer intervention

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a gen...

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Autores principales: Liu, Wenjun, Palovcak, Anna, Li, Fang, Zafar, Alyan, Yuan, Fenghua, Zhang, Yanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075017/
https://www.ncbi.nlm.nih.gov/pubmed/32190289
http://dx.doi.org/10.1186/s13578-020-00401-7
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author Liu, Wenjun
Palovcak, Anna
Li, Fang
Zafar, Alyan
Yuan, Fenghua
Zhang, Yanbin
author_facet Liu, Wenjun
Palovcak, Anna
Li, Fang
Zafar, Alyan
Yuan, Fenghua
Zhang, Yanbin
author_sort Liu, Wenjun
collection PubMed
description Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a genetic vulnerability for cancer predisposition. The cancer relevance of the FA pathway is further established with the pervasive occurrence of FA gene alterations in somatic cancers and observations of FA pathway activation-associated chemotherapy resistance. In this article we describe the role of the FA pathway in canonical interstrand crosslink (ICL) repair and possible contributions of FA gene alterations to cancer development. We also discuss the perspectives and potential of targeting the FA pathway for cancer intervention.
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spelling pubmed-70750172020-03-18 Fanconi anemia pathway as a prospective target for cancer intervention Liu, Wenjun Palovcak, Anna Li, Fang Zafar, Alyan Yuan, Fenghua Zhang, Yanbin Cell Biosci Review Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a genetic vulnerability for cancer predisposition. The cancer relevance of the FA pathway is further established with the pervasive occurrence of FA gene alterations in somatic cancers and observations of FA pathway activation-associated chemotherapy resistance. In this article we describe the role of the FA pathway in canonical interstrand crosslink (ICL) repair and possible contributions of FA gene alterations to cancer development. We also discuss the perspectives and potential of targeting the FA pathway for cancer intervention. BioMed Central 2020-03-16 /pmc/articles/PMC7075017/ /pubmed/32190289 http://dx.doi.org/10.1186/s13578-020-00401-7 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Liu, Wenjun
Palovcak, Anna
Li, Fang
Zafar, Alyan
Yuan, Fenghua
Zhang, Yanbin
Fanconi anemia pathway as a prospective target for cancer intervention
title Fanconi anemia pathway as a prospective target for cancer intervention
title_full Fanconi anemia pathway as a prospective target for cancer intervention
title_fullStr Fanconi anemia pathway as a prospective target for cancer intervention
title_full_unstemmed Fanconi anemia pathway as a prospective target for cancer intervention
title_short Fanconi anemia pathway as a prospective target for cancer intervention
title_sort fanconi anemia pathway as a prospective target for cancer intervention
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075017/
https://www.ncbi.nlm.nih.gov/pubmed/32190289
http://dx.doi.org/10.1186/s13578-020-00401-7
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