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Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism
Biodegradable polymers hold great therapeutic value, especially through the addition of additives for controlled drug release. Nanocellulose has shown promise in drug delivery, yet usually requires chemical crosslinking with harsh acids and solvents. Nanocellulose fibrils (NFCs) and 2,2,6,6-tetramet...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075188/ https://www.ncbi.nlm.nih.gov/pubmed/32050630 http://dx.doi.org/10.3390/nano10020301 |
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author | O’Donnell, Kelsey L. Oporto-Velásquez, Gloria S. Comolli, Noelle |
author_facet | O’Donnell, Kelsey L. Oporto-Velásquez, Gloria S. Comolli, Noelle |
author_sort | O’Donnell, Kelsey L. |
collection | PubMed |
description | Biodegradable polymers hold great therapeutic value, especially through the addition of additives for controlled drug release. Nanocellulose has shown promise in drug delivery, yet usually requires chemical crosslinking with harsh acids and solvents. Nanocellulose fibrils (NFCs) and 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO)-mediated oxidized nanocellulose fibrils (TNFCs) with poly (vinyl alcohol) (PVA) could be aqueously formulated to control the release of model drug acetaminophen over 144 h. The release was evaluated with a multiphase release mechanism to determine which mechanism(s) contribute to the overall release and to what degree. Doing so indicated that the TNFCs in PVA control the release of acetaminophen more than NFCs in PVA. Modeling showed that this release was mostly due to burst release—drug coming off the immediate surface, rather than diffusing out of the matrix. |
format | Online Article Text |
id | pubmed-7075188 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-70751882020-03-20 Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism O’Donnell, Kelsey L. Oporto-Velásquez, Gloria S. Comolli, Noelle Nanomaterials (Basel) Article Biodegradable polymers hold great therapeutic value, especially through the addition of additives for controlled drug release. Nanocellulose has shown promise in drug delivery, yet usually requires chemical crosslinking with harsh acids and solvents. Nanocellulose fibrils (NFCs) and 2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPO)-mediated oxidized nanocellulose fibrils (TNFCs) with poly (vinyl alcohol) (PVA) could be aqueously formulated to control the release of model drug acetaminophen over 144 h. The release was evaluated with a multiphase release mechanism to determine which mechanism(s) contribute to the overall release and to what degree. Doing so indicated that the TNFCs in PVA control the release of acetaminophen more than NFCs in PVA. Modeling showed that this release was mostly due to burst release—drug coming off the immediate surface, rather than diffusing out of the matrix. MDPI 2020-02-10 /pmc/articles/PMC7075188/ /pubmed/32050630 http://dx.doi.org/10.3390/nano10020301 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article O’Donnell, Kelsey L. Oporto-Velásquez, Gloria S. Comolli, Noelle Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism |
title | Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism |
title_full | Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism |
title_fullStr | Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism |
title_full_unstemmed | Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism |
title_short | Evaluation of Acetaminophen Release from Biodegradable Poly (Vinyl Alcohol) (PVA) and Nanocellulose Films Using a Multiphase Release Mechanism |
title_sort | evaluation of acetaminophen release from biodegradable poly (vinyl alcohol) (pva) and nanocellulose films using a multiphase release mechanism |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075188/ https://www.ncbi.nlm.nih.gov/pubmed/32050630 http://dx.doi.org/10.3390/nano10020301 |
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