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Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials

With the development of nanotechnology in recent years, there have been concerns about the health effects of nanoparticles. Carbon nanotubes (CNTs) are fibrous nanoparticles with a micro-sized length and nano-sized diameter, which exhibit excellent physical properties and are widely studied for thei...

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Detalles Bibliográficos
Autores principales: Aoki, Kaoru, Saito, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075247/
https://www.ncbi.nlm.nih.gov/pubmed/32033249
http://dx.doi.org/10.3390/nano10020264
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author Aoki, Kaoru
Saito, Naoto
author_facet Aoki, Kaoru
Saito, Naoto
author_sort Aoki, Kaoru
collection PubMed
description With the development of nanotechnology in recent years, there have been concerns about the health effects of nanoparticles. Carbon nanotubes (CNTs) are fibrous nanoparticles with a micro-sized length and nano-sized diameter, which exhibit excellent physical properties and are widely studied for their potential application in medicine. However, asbestos has been historically shown to cause pleural malignant mesothelioma and lung cancer by inhalation exposure. Because carbon nanotubes are also fibrous nanotubes, some have raised concerns about its possible carcinogenicity. We have reported that there is no clear evidence of carcinogenicity by local and intravenous administration of multi-walled CNTs to cancer mice models. We firmly believe that CNTs can be a safe, new, and high-performance biomaterials by controlling its type, site of administration, and dosage.
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spelling pubmed-70752472020-03-20 Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials Aoki, Kaoru Saito, Naoto Nanomaterials (Basel) Review With the development of nanotechnology in recent years, there have been concerns about the health effects of nanoparticles. Carbon nanotubes (CNTs) are fibrous nanoparticles with a micro-sized length and nano-sized diameter, which exhibit excellent physical properties and are widely studied for their potential application in medicine. However, asbestos has been historically shown to cause pleural malignant mesothelioma and lung cancer by inhalation exposure. Because carbon nanotubes are also fibrous nanotubes, some have raised concerns about its possible carcinogenicity. We have reported that there is no clear evidence of carcinogenicity by local and intravenous administration of multi-walled CNTs to cancer mice models. We firmly believe that CNTs can be a safe, new, and high-performance biomaterials by controlling its type, site of administration, and dosage. MDPI 2020-02-04 /pmc/articles/PMC7075247/ /pubmed/32033249 http://dx.doi.org/10.3390/nano10020264 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Aoki, Kaoru
Saito, Naoto
Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
title Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
title_full Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
title_fullStr Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
title_full_unstemmed Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
title_short Biocompatibility and Carcinogenicity of Carbon Nanotubes as Biomaterials
title_sort biocompatibility and carcinogenicity of carbon nanotubes as biomaterials
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075247/
https://www.ncbi.nlm.nih.gov/pubmed/32033249
http://dx.doi.org/10.3390/nano10020264
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