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eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide

The translation preinitiation complex (PIC) scans the mRNA for an AUG codon in a favorable context. Previous findings suggest that the factor eIF1 discriminates against non-AUG start codons by impeding full accommodation of Met-tRNA(i) in the P site of the 40S ribosomal subunit, necessitating eIF1 d...

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Detalles Bibliográficos
Autores principales:	Zhou, Fujun, Zhang, Hongen, Kulkarni, Shardul D., Lorsch, Jon R., Hinnebusch, Alan G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075259/ https://www.ncbi.nlm.nih.gov/pubmed/31915290 http://dx.doi.org/10.1261/rna.073536.119

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