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Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System

Treatment of certain diseases requires the administration of drugs at specific areas of tissues and/or organs to increase therapy effectiveness and avoid side effects that may harm the rest of the body. Drug targeting is a research field that uses various techniques to administrate therapies at spec...

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Autores principales: Banis, Georgios, Tyrovolas, Konstantinos, Angelopoulos, Spyridon, Ferraro, Angelo, Hristoforou, Evangelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075344/
https://www.ncbi.nlm.nih.gov/pubmed/32093280
http://dx.doi.org/10.3390/nano10020371
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author Banis, Georgios
Tyrovolas, Konstantinos
Angelopoulos, Spyridon
Ferraro, Angelo
Hristoforou, Evangelos
author_facet Banis, Georgios
Tyrovolas, Konstantinos
Angelopoulos, Spyridon
Ferraro, Angelo
Hristoforou, Evangelos
author_sort Banis, Georgios
collection PubMed
description Treatment of certain diseases requires the administration of drugs at specific areas of tissues and/or organs to increase therapy effectiveness and avoid side effects that may harm the rest of the body. Drug targeting is a research field that uses various techniques to administrate therapies at specific areas of the body, including magnetic systems able to drive nano “vehicles”, as well as magnetically labeled molecules, in human body fluids and tissues. Most available actuation systems can only attract magnetic elements in a relatively small workspace, limiting drug target applications to superficial tissues, and leaving no alternative cases where deep targeting is necessary. In this paper, we propose an electromagnetic actuation system able to push and deflect magnetic particles at distance of ~10 cm, enabling the manipulation of magnetic nano- and microparticles, as well as administration of drugs in tissues, which are not eligible for localized drug targeting with state-of-the-art systems. Laboratory experiments and modeling were conducted to prove the effectiveness of the proposed system. By further implementing our device, areas of the human body that previously were impossible to treat with magnetically labeled materials such as drugs, cells, and small molecules can now be accessible using the described system.
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spelling pubmed-70753442020-03-20 Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System Banis, Georgios Tyrovolas, Konstantinos Angelopoulos, Spyridon Ferraro, Angelo Hristoforou, Evangelos Nanomaterials (Basel) Article Treatment of certain diseases requires the administration of drugs at specific areas of tissues and/or organs to increase therapy effectiveness and avoid side effects that may harm the rest of the body. Drug targeting is a research field that uses various techniques to administrate therapies at specific areas of the body, including magnetic systems able to drive nano “vehicles”, as well as magnetically labeled molecules, in human body fluids and tissues. Most available actuation systems can only attract magnetic elements in a relatively small workspace, limiting drug target applications to superficial tissues, and leaving no alternative cases where deep targeting is necessary. In this paper, we propose an electromagnetic actuation system able to push and deflect magnetic particles at distance of ~10 cm, enabling the manipulation of magnetic nano- and microparticles, as well as administration of drugs in tissues, which are not eligible for localized drug targeting with state-of-the-art systems. Laboratory experiments and modeling were conducted to prove the effectiveness of the proposed system. By further implementing our device, areas of the human body that previously were impossible to treat with magnetically labeled materials such as drugs, cells, and small molecules can now be accessible using the described system. MDPI 2020-02-20 /pmc/articles/PMC7075344/ /pubmed/32093280 http://dx.doi.org/10.3390/nano10020371 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Banis, Georgios
Tyrovolas, Konstantinos
Angelopoulos, Spyridon
Ferraro, Angelo
Hristoforou, Evangelos
Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System
title Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System
title_full Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System
title_fullStr Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System
title_full_unstemmed Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System
title_short Pushing of Magnetic Microdroplet Using Electromagnetic Actuation System
title_sort pushing of magnetic microdroplet using electromagnetic actuation system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075344/
https://www.ncbi.nlm.nih.gov/pubmed/32093280
http://dx.doi.org/10.3390/nano10020371
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