Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

[Image: see text] The hexameric α-helical coiled-coil formed between the C-terminal and N-terminal heptad repeat (CHR and NHR) regions of class I viral fusion proteins plays an important role in mediating the fusion of the viral and cellular membranes and provides a clear starting point for molecula...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Xia, Shuai, Zhang, Peiyu, Zhang, Tianhong, Wang, Weicong, Tian, Yangli, Meng, Guangpeng, Jiang, Shibo, Liu, Keliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075646/
https://www.ncbi.nlm.nih.gov/pubmed/29442512
http://dx.doi.org/10.1021/acs.jmedchem.7b01732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075646/
https://www.ncbi.nlm.nih.gov/pubmed/29442512
http://dx.doi.org/10.1021/acs.jmedchem.7b01732

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