De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

[Image: see text] Class I enveloped viruses share similarities in their apparent use of a hexameric coiled-coil assembly to drive the merging of virus and host cell membranes. Inhibition of coiled coil-mediated interactions using bioactive peptides that replicate an α-helical chain from the viral fu...

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Detalles Bibliográficos
Autores principales: Wang, Chao, Zhao, Lei, Xia, Shuai, Zhang, Tianhong, Cao, Ruiyuan, Liang, Guodong, Li, Yue, Meng, Guangpeng, Wang, Weicong, Shi, Weiguo, Zhong, Wu, Jiang, Shibo, Liu, Keliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075651/
https://www.ncbi.nlm.nih.gov/pubmed/30192544
http://dx.doi.org/10.1021/acs.jmedchem.8b00890

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