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BMD42-2910, a Novel Benzoxazole Derivative, Shows a Potent Anti-prion Activity and Prolongs the Mean Survival in an Animal Model of Prion Disease
Prion diseases are a group of neurodegenerative and fatal central nervous system disorders. The pathogenic mechanism involves the conversion of cellular prion protein (PrP(C)) to an altered scrapie isoform (PrP(Sc)), which accumulates in amyloid deposits in the brain. However, no therapeutic drugs h...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Society for Brain and Neural Sciences
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075655/ https://www.ncbi.nlm.nih.gov/pubmed/32122111 http://dx.doi.org/10.5607/en.2020.29.1.93 |