Trans-Cyclooctene-Functionalized PeptoBrushes with Improved Reaction Kinetics of the Tetrazine Ligation for Pretargeted Nuclear Imaging

[Image: see text] Tumor targeting using agents with slow pharmacokinetics represents a major challenge in nuclear imaging and targeted radionuclide therapy as they most often result in low imaging contrast and high radiation dose to healthy tissue. To address this challenge, we developed a polymer-b...

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Detalles Bibliográficos
Autores principales: Stéen, E. Johanna L., Jørgensen, Jesper T., Johann, Kerstin, Nørregaard, Kamilla, Sohr, Barbara, Svatunek, Dennis, Birke, Alexander, Shalgunov, Vladimir, Edem, Patricia E., Rossin, Raffaella, Seidl, Christine, Schmid, Friederike, Robillard, Marc S., Kristensen, Jesper L., Mikula, Hannes, Barz, Matthias, Kjær, Andreas, Herth, Matthias M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075664/
https://www.ncbi.nlm.nih.gov/pubmed/31820928
http://dx.doi.org/10.1021/acsnano.9b06905

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