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Liquisolid System and Liqui-Mass System Are Not the Same
This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. Despite some similarities, there are crucial differences separating these two technologies. Liqui-Pellet uses liqui-mass system (wet mass/paste admixture...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075839/ https://www.ncbi.nlm.nih.gov/pubmed/32180042 http://dx.doi.org/10.1208/s12249-020-01650-y |
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author | Lam, Matthew Ghafourian, Taravat Nokhodchi, Ali |
author_facet | Lam, Matthew Ghafourian, Taravat Nokhodchi, Ali |
author_sort | Lam, Matthew |
collection | PubMed |
description | This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. Despite some similarities, there are crucial differences separating these two technologies. Liqui-Pellet uses liqui-mass system (wet mass/paste admixture), and liquisolid pellet uses liquisolid system (flowable powder admixture). The understanding of the well-defined term ‘liquisolid system’ is crucial to understand what is and is not liquisolid formulation. Spireas, who is the inventor of liquisolid technology, clearly defined liquisolid system in his patent document and publications. Since his first publication in 1998, there are around 200 articles about liquisolid formulations (extracted from Scopus), and with no exception, every single one of them followed the original definition of liquisolid system. Liqui-Pellet does not use liquisolid system and so calling it the same as liquisolid pellet, which uses liquisolid system, is incorrect and misleading. The purpose of this commentary is to resolve misunderstanding and support furthering knowledge. |
format | Online Article Text |
id | pubmed-7075839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-70758392020-03-23 Liquisolid System and Liqui-Mass System Are Not the Same Lam, Matthew Ghafourian, Taravat Nokhodchi, Ali AAPS PharmSciTech Commentary This commentary is written in response to Pezzini’s research group commentary, which claimed Liqui-Pellet and liquisolid pellet are not different. Despite some similarities, there are crucial differences separating these two technologies. Liqui-Pellet uses liqui-mass system (wet mass/paste admixture), and liquisolid pellet uses liquisolid system (flowable powder admixture). The understanding of the well-defined term ‘liquisolid system’ is crucial to understand what is and is not liquisolid formulation. Spireas, who is the inventor of liquisolid technology, clearly defined liquisolid system in his patent document and publications. Since his first publication in 1998, there are around 200 articles about liquisolid formulations (extracted from Scopus), and with no exception, every single one of them followed the original definition of liquisolid system. Liqui-Pellet does not use liquisolid system and so calling it the same as liquisolid pellet, which uses liquisolid system, is incorrect and misleading. The purpose of this commentary is to resolve misunderstanding and support furthering knowledge. Springer International Publishing 2020-03-16 /pmc/articles/PMC7075839/ /pubmed/32180042 http://dx.doi.org/10.1208/s12249-020-01650-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Commentary Lam, Matthew Ghafourian, Taravat Nokhodchi, Ali Liquisolid System and Liqui-Mass System Are Not the Same |
title | Liquisolid System and Liqui-Mass System Are Not the Same |
title_full | Liquisolid System and Liqui-Mass System Are Not the Same |
title_fullStr | Liquisolid System and Liqui-Mass System Are Not the Same |
title_full_unstemmed | Liquisolid System and Liqui-Mass System Are Not the Same |
title_short | Liquisolid System and Liqui-Mass System Are Not the Same |
title_sort | liquisolid system and liqui-mass system are not the same |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075839/ https://www.ncbi.nlm.nih.gov/pubmed/32180042 http://dx.doi.org/10.1208/s12249-020-01650-y |
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