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Delineating elastic properties of kinesin linker and their sensitivity to point mutations
We analyze free energy estimators from simulation trials mimicking single-molecule pulling experiments on a neck linker of a kinesin motor. For that purpose, we have performed a version of steered molecular dynamics (SMD) calculations. The sample trajectories have been analyzed to derive distributio...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075872/ https://www.ncbi.nlm.nih.gov/pubmed/32179821 http://dx.doi.org/10.1038/s41598-020-61399-z |