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Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model

Ticks are arthropod ectoparasite vectors of pathogens and the cause of allergic reactions affecting human health worldwide. In humans, tick bites can induce high levels of immunoglobulin E antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present in glycoproteins and glycolipids...

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Autores principales: Contreras, Marinela, Pacheco, Iván, Alberdi, Pilar, Díaz-Sánchez, Sandra, Artigas-Jerónimo, Sara, Mateos-Hernández, Lourdes, Villar, Margarita, Cabezas-Cruz, Alejandro, de la Fuente, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075944/
https://www.ncbi.nlm.nih.gov/pubmed/32211341
http://dx.doi.org/10.3389/fcimb.2020.00078
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author Contreras, Marinela
Pacheco, Iván
Alberdi, Pilar
Díaz-Sánchez, Sandra
Artigas-Jerónimo, Sara
Mateos-Hernández, Lourdes
Villar, Margarita
Cabezas-Cruz, Alejandro
de la Fuente, José
author_facet Contreras, Marinela
Pacheco, Iván
Alberdi, Pilar
Díaz-Sánchez, Sandra
Artigas-Jerónimo, Sara
Mateos-Hernández, Lourdes
Villar, Margarita
Cabezas-Cruz, Alejandro
de la Fuente, José
author_sort Contreras, Marinela
collection PubMed
description Ticks are arthropod ectoparasite vectors of pathogens and the cause of allergic reactions affecting human health worldwide. In humans, tick bites can induce high levels of immunoglobulin E antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present in glycoproteins and glycolipids from tick saliva that mediate anaphylactic reactions known as the alpha-Gal syndrome (AGS) or red meat allergy. In this study, a new animal model was developed using zebrafish for the study of allergic reactions and the immune mechanisms in response to tick salivary biogenic substances and red meat consumption. The results showed allergic hemorrhagic anaphylactic-type reactions and abnormal behavior patterns likely in response to tick salivary toxic and anticoagulant biogenic compounds different from α-Gal. However, the results showed that only zebrafish previously exposed to tick saliva developed allergic reactions to red meat consumption with rapid desensitization and tolerance. These allergic reactions were associated with tissue-specific Toll-like receptor-mediated responses in types 1 and 2 T helper cells (T(H)1 and T(H)2) with a possible role for basophils in response to tick saliva. These results support previously proposed immune mechanisms triggering the AGS and provided evidence for new mechanisms also potentially involved in the AGS. These results support the use of the zebrafish animal model for the study of the AGS and other tick-borne allergies.
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spelling pubmed-70759442020-03-24 Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model Contreras, Marinela Pacheco, Iván Alberdi, Pilar Díaz-Sánchez, Sandra Artigas-Jerónimo, Sara Mateos-Hernández, Lourdes Villar, Margarita Cabezas-Cruz, Alejandro de la Fuente, José Front Cell Infect Microbiol Cellular and Infection Microbiology Ticks are arthropod ectoparasite vectors of pathogens and the cause of allergic reactions affecting human health worldwide. In humans, tick bites can induce high levels of immunoglobulin E antibodies against the carbohydrate Galα1-3Galβ1-(3)4GlcNAc-R (α-Gal) present in glycoproteins and glycolipids from tick saliva that mediate anaphylactic reactions known as the alpha-Gal syndrome (AGS) or red meat allergy. In this study, a new animal model was developed using zebrafish for the study of allergic reactions and the immune mechanisms in response to tick salivary biogenic substances and red meat consumption. The results showed allergic hemorrhagic anaphylactic-type reactions and abnormal behavior patterns likely in response to tick salivary toxic and anticoagulant biogenic compounds different from α-Gal. However, the results showed that only zebrafish previously exposed to tick saliva developed allergic reactions to red meat consumption with rapid desensitization and tolerance. These allergic reactions were associated with tissue-specific Toll-like receptor-mediated responses in types 1 and 2 T helper cells (T(H)1 and T(H)2) with a possible role for basophils in response to tick saliva. These results support previously proposed immune mechanisms triggering the AGS and provided evidence for new mechanisms also potentially involved in the AGS. These results support the use of the zebrafish animal model for the study of the AGS and other tick-borne allergies. Frontiers Media S.A. 2020-03-10 /pmc/articles/PMC7075944/ /pubmed/32211341 http://dx.doi.org/10.3389/fcimb.2020.00078 Text en Copyright © 2020 Contreras, Pacheco, Alberdi, Díaz-Sánchez, Artigas-Jerónimo, Mateos-Hernández, Villar, Cabezas-Cruz and de la Fuente. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Contreras, Marinela
Pacheco, Iván
Alberdi, Pilar
Díaz-Sánchez, Sandra
Artigas-Jerónimo, Sara
Mateos-Hernández, Lourdes
Villar, Margarita
Cabezas-Cruz, Alejandro
de la Fuente, José
Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model
title Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model
title_full Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model
title_fullStr Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model
title_full_unstemmed Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model
title_short Allergic Reactions and Immunity in Response to Tick Salivary Biogenic Substances and Red Meat Consumption in the Zebrafish Model
title_sort allergic reactions and immunity in response to tick salivary biogenic substances and red meat consumption in the zebrafish model
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075944/
https://www.ncbi.nlm.nih.gov/pubmed/32211341
http://dx.doi.org/10.3389/fcimb.2020.00078
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