Novel Lipidated Imidazoquinoline TLR7/8 Adjuvants Elicit Influenza-Specific Th1 Immune Responses and Protect Against Heterologous H3N2 Influenza Challenge in Mice

Most licensed seasonal influenza vaccines are non-adjuvanted and rely primarily on vaccine-induced antibody titers for protection. As such, seasonal antigenic drift and suboptimal vaccine strain selection often results in reduced vaccine efficacy. Further, seasonal H3N2 influenza vaccines demonstrat...

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Detalles Bibliográficos
Autores principales: Miller, Shannon M., Cybulski, Van, Whitacre, Margaret, Bess, Laura S., Livesay, Mark T., Walsh, Lois, Burkhart, David, Bazin, Hélène G., Evans, Jay T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7075946/
https://www.ncbi.nlm.nih.gov/pubmed/32210973
http://dx.doi.org/10.3389/fimmu.2020.00406

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