Progesterone receptor membrane component 1 leads to erlotinib resistance, initiating crosstalk of Wnt/β-catenin and NF-κB pathways, in lung adenocarcinoma cells

In non-small-cell lung cancer, mutation of epidermal growth factor receptor (EGFR) stimulates cell proliferation and survival. EGFR tyrosine kinase inhibitors (EGFR-TKIs) such as erlotinib are used as first-line therapy with drastic and immediate effectiveness. However, the disease eventually progre...

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Detalles Bibliográficos
Autores principales: Lin, Ying, Higashisaka, Kazuma, Shintani, Takuya, Maki, Ayaka, Hanamuro, Sachiyo, Haga, Yuya, Maeda, Shinichiro, Tsujino, Hirofumi, Nagano, Kazuya, Fujio, Yasushi, Tsutsumi, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076038/
https://www.ncbi.nlm.nih.gov/pubmed/32179851
http://dx.doi.org/10.1038/s41598-020-61727-3

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