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Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together
Patients with Parkinson’s disease (PD) generally have reduced risk of developing many types of cancers, except melanoma—a malignant tumor of melanin-producing cells in the skin. For decades, a large number of epidemiological studies have reported that the occurrence of melanoma is higher than expect...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076116/ https://www.ncbi.nlm.nih.gov/pubmed/32210791 http://dx.doi.org/10.3389/fnagi.2020.00060 |
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author | Ye, Qing Wen, Ya Al-Kuwari, Nasser Chen, Xiqun |
author_facet | Ye, Qing Wen, Ya Al-Kuwari, Nasser Chen, Xiqun |
author_sort | Ye, Qing |
collection | PubMed |
description | Patients with Parkinson’s disease (PD) generally have reduced risk of developing many types of cancers, except melanoma—a malignant tumor of melanin-producing cells in the skin. For decades, a large number of epidemiological studies have reported that the occurrence of melanoma is higher than expected among subjects with PD, and the occurrence of PD is reciprocally higher than expected among patients with melanoma. More recent epidemiological studies further indicated a bidirectional association, not only in the patients themselves but also in their relatives. This association between PD and melanoma offers a unique opportunity to understand PD. Here, we summarize epidemiological, clinical, and biological evidence in regard to shared risk factors and possible underlying mechanisms for these two seemingly distinct conditions. |
format | Online Article Text |
id | pubmed-7076116 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-70761162020-03-24 Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together Ye, Qing Wen, Ya Al-Kuwari, Nasser Chen, Xiqun Front Aging Neurosci Neuroscience Patients with Parkinson’s disease (PD) generally have reduced risk of developing many types of cancers, except melanoma—a malignant tumor of melanin-producing cells in the skin. For decades, a large number of epidemiological studies have reported that the occurrence of melanoma is higher than expected among subjects with PD, and the occurrence of PD is reciprocally higher than expected among patients with melanoma. More recent epidemiological studies further indicated a bidirectional association, not only in the patients themselves but also in their relatives. This association between PD and melanoma offers a unique opportunity to understand PD. Here, we summarize epidemiological, clinical, and biological evidence in regard to shared risk factors and possible underlying mechanisms for these two seemingly distinct conditions. Frontiers Media S.A. 2020-03-10 /pmc/articles/PMC7076116/ /pubmed/32210791 http://dx.doi.org/10.3389/fnagi.2020.00060 Text en Copyright © 2020 Ye, Wen, Al-Kuwari and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Ye, Qing Wen, Ya Al-Kuwari, Nasser Chen, Xiqun Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together |
title | Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together |
title_full | Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together |
title_fullStr | Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together |
title_full_unstemmed | Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together |
title_short | Association Between Parkinson’s Disease and Melanoma: Putting the Pieces Together |
title_sort | association between parkinson’s disease and melanoma: putting the pieces together |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076116/ https://www.ncbi.nlm.nih.gov/pubmed/32210791 http://dx.doi.org/10.3389/fnagi.2020.00060 |
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